Cholinesterase inhibitors modify the activity of intrinsic cardiac neurons

Experimental Neurology
Sultan DarveshJ Andrew Armour

Abstract

Cholinesterase inhibitors used to treat the symptoms of Alzheimer's disease (AD) inhibit both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), albeit to different degrees. Because central and peripheral neurons, including intrinsic cardiac neurons located on the surface of the mammalian heart, express both BuChE and AChE, we studied spontaneously active intrinsic cardiac neurons in the pig as a model to assess the effects of inhibition of AChE compared to BuChE. Neuroanatomical experiments showed that some porcine intrinsic cardiac neurons expressed AChE and/or BuChE. Enzyme kinetic experiments with cholinesterase inhibitors, namely, donepezil, galantamine, (+/-) huperzine A, metrifonate, rivastigmine, and tetrahydroaminoacridine, demonstrated that these compounds differentially inhibited porcine AChE and BuChE. Donepezil and (+/-) huperzine A were better reversible inhibitors of AChE, and galantamine equally inhibited both the enzymes. Tetrahydroaminoacridine was a better reversible inhibitor of BuChE. Rivastigmine caused more rapid inactivation of BuChE as compared to AChE. Neurophysiological studies showed that acetylcholine and butyrylcholine increase or decrease the spontaneous activity of the intrinsic cardi...Continue Reading

References

Oct 13, 1978·Archives of Toxicology·I NordgrenM Sandoz
Jan 1, 1977·Circulation Research·D V PriolaW P Geis
Nov 8, 1992·The Journal of Comparative Neurology·H TagoH Kimura
Jul 30, 1982·Science·R T BartusA S Lippa
Jan 1, 1995·Acta Neurologica Scandinavica·A AlgotssonG Solders
Sep 1, 1994·Age and Ageing·S J WangH C Liu
Oct 1, 1993·Biological Psychiatry·B VitielloT Sunderland
Apr 1, 1993·British Journal of Pharmacology·X NorelC Brink
Mar 27, 1997·Journal of Biochemical and Biophysical Methods·J GrunwaldY Ashani
Jul 1, 1997·Japanese Journal of Pharmacology·E Giacobini
Oct 6, 1998·Journal of the Autonomic Nervous System·S DarveshJ A Armour
Jan 7, 1999·Alzheimer Disease and Associated Disorders·F GiubileiC Fieschi
May 20, 1999·The Annals of Pharmacotherapy·W J KrallN R Cutler
Mar 23, 2001·Acta Neurologica Scandinavica. Supplementum·N H GreigT T Soncrant
Jan 29, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·R C AroraJ A Armour
Feb 4, 2003·Nature Reviews. Neuroscience·Sultan DarveshChangiz Geula
Jun 10, 2003·Alzheimer Disease and Associated Disorders·Sultan DarveshEarl Martin
Jun 18, 2003·The Journal of Comparative Neurology·Sultan Darvesh, David A Hopkins
Mar 1, 1964·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M J KARNOVSKY, L ROOTS

❮ Previous
Next ❯

Citations

May 28, 2010·Alzheimer Disease and Associated Disorders·Michael H RosenbloomGil D Rabinovici
Nov 28, 2008·American Journal of Physiology. Cell Physiology·Nirish ShahJean-Pierre Raufman
Feb 13, 2014·The Journal of Emergency Medicine·Umberto RaucciNicola Pirozzi
May 1, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Rômulo Pillon BarcelosNilda Berenice de Vargas Barbosa
Jul 30, 2005·World Journal of Gastroenterology : WJG·Shan-Zhi GuBo-Rong Pan
Apr 5, 2018·Frontiers in Physiology·Jesse L AshtonJohanna M Montgomery
Feb 8, 2018·Biochemical Pharmacology·Carey N Pope, Stephen Brimijoin
Feb 22, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jere R VirtaJuha O Rinne

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.