Cholinesterases characterization of three tropical fish species, and their sensitivity towards specific contaminants

Ecotoxicology and Environmental Safety
Beatriz V R PereiraBruno Nunes

Abstract

Cholinesterases are frequent targets for toxic effects, namely by insecticides derived from phosphoric and carbamic acids. This effects allows the use of cholinesterase inhibition as a biomarker for contamination of aquatic environments by these specific chemical agents. However, cholinesterases are differently responsive to environmental contaminants, according to their different forms and locations. In addition, cholinesterases seem also to be inhibited by metals, so their use as an environmental criterion requires the prior characterization of their specific forms in each species and tissues, and the study of their sensitivity. The objective of this study was to characterize the cholinesterase isoenzymes present in the brain and dorsal muscle of three tropical fish species, namely Phalloceros harpagos (Lucinda, 2008), Pterygoplichthys pardalis (Castelnau, 1855) and Astyanax altiparanae (Garutti and Britski, 2000). In vitro assays were conducted to quantify the effect of pesticides (dimethoate and carbaryl) and metals (lead and copper) on cholinesterases activity. Although acetylcholinesterase seems to be the most prevalent and abundant form, as commonly described in vertebrates, the here-obtained results showed that three ch...Continue Reading

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Citations

Apr 30, 2020·Bulletin of Environmental Contamination and Toxicology·Renato Matos Lopes
Nov 30, 2020·The Science of the Total Environment·Manuela S SantanaMaritana Mela Prodocimo
Apr 30, 2021·Environmental Science and Pollution Research International·Madalena Vieira, Bruno Nunes

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