Chondrocyte biosynthesis correlates with local tissue strain in statically compressed adult articular cartilage

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
M WongE Hunziker

Abstract

In this study, we investigated the depth-dependent metabolic and structural responses of adult articular cartilage to large-strain, static, unconfined compression. Changes in cell biosynthetic activity and several morphometry-based structural parameters (cell density, cell volume fraction, cell surface-area density, mean cell surface area, and mean cell volume) were measured at eight sites representing different depth-zones between the articular surface and the cartilage/bone border. In addition, local axial strain in the superficial, transitional, upper radial, and lower radial zones was estimated on the basis of the change in cell density values. Static compression of articular cartilage revealed a highly heterogeneous deformation profile through the depth of the sample as well as zone-specific changes in biosynthetic activity, as reflected by incorporation of [3H]proline. The axial strains in the top layers were greater than the applied surface-to-surface strain, whereas axial strains adjacent to the cartilage/bone border were significantly less than the applied strain. Zonal changes in cell density and axial strain that occurred during static compression correlated well with alterations in metabolic activity. These coordina...Continue Reading

References

Jul 17, 1975·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Maroudas
Jan 1, 1986·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R SchneidermanA Maroudas
Jan 1, 1988·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M L GrayR C Lee
Sep 1, 1972·Annals of the Rheumatic Diseases·R A Stockwell
Sep 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·N N BoustanyE B Hunziker
May 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·F GuilakV C Mow
Oct 1, 1994·British Journal of Rheumatology·J P Urban
May 1, 1996·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M D BuschmannE B Hunziker
May 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M WongE Hunziker

❮ Previous
Next ❯

Citations

Jun 24, 2011·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·M R SteinwachsP Niemeyer
Feb 24, 2007·European Biophysics Journal : EBJ·Ronny Maik Schulz, Augustinus Bader
Sep 1, 2006·Cell and Tissue Research·Sriram V EleswarapuKyriacos A Athanasiou
Mar 1, 2006·Biomechanics and Modeling in Mechanobiology·S-K HanW Herzog
Mar 8, 2006·Biomechanics and Modeling in Mechanobiology·Mansoor A HaiderFarshid Guilak
Mar 15, 2006·Biomechanics and Modeling in Mechanobiology·W Herzog, S Federico
Aug 10, 2006·Annals of Biomedical Engineering·Adam C Aufderheide, Kyriacos A Athanasiou
May 17, 2006·Acta Biomaterialia·Leonidas G AlexopoulosFarshid Guilak
Oct 3, 2003·Biochemical and Biophysical Research Communications·O DémarteauI Martin
Feb 6, 2004·Journal of Biomechanics·Andrew J L Walsh, Jeffrey C Lotz
Sep 20, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·P G Bush, A C Hall
Jan 1, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Takashi IkenoueR Lane Smith
Dec 22, 1999·Matrix Biology : Journal of the International Society for Matrix Biology·M Chiquet
Mar 11, 2011·Computer Methods in Biomechanics and Biomedical Engineering·Lars JohanssonPer Aspenberg
Jun 15, 2006·Tissue Engineering·Jerry C Hu, Kyriacos A Athanasiou
Oct 17, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Dennis R Carter, Marcy Wong
Sep 4, 2009·Journal of Biomechanical Engineering·Lars JohanssonPer Aspenberg
Nov 10, 2001·Annual Review of Biomedical Engineering·A J GrodzinskyE H Frank
Oct 26, 2010·BMC Developmental Biology·Mark C van TurnhoutJohan L van Leeuwen
Feb 21, 2009·The Journal of Bone and Joint Surgery. American Volume·Thomas P AndriacchiSean F Scanlan
Jun 8, 2010·Biomechanics and Modeling in Mechanobiology·Mark C van TurnhoutJohan L van Leeuwen
Jan 7, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M J KääbH P Nötzli
Dec 29, 2015·Osteoarthritis and Cartilage·N H Varady, A J Grodzinsky

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Farshid GuilakV C Mow
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
R M SchinaglR L Sah
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
R L SahJ D Sandy
© 2021 Meta ULC. All rights reserved