Chondrocyte proliferation regulated by secreted luminal domain of ER stress transducer BBF2H7/CREB3L2

Molecular Cell
Atsushi SaitoKazunori Imaizumi

Abstract

The endoplasmic reticulum (ER) stress transducer BBF2H7/CREB3L2 is an ER-resident transmembrane transcription factor. In response to physiological ER stress, it is processed at the transmembrane region to generate a cytoplasmic N terminus, which contains a basic leucine zipper (bZIP) domain, and luminal C terminus. The BBF2H7 N terminus functions as a transcription factor to promote the expression of ER-Golgi trafficking-related genes and plays crucial roles in chondrocyte differentiation. Here, we found that the BBF2H7 C terminus is secreted into the extracellular space as a signaling molecule for cell-to-cell communication. The secreted BBF2H7 C terminus directly binds to both Indian hedgehog and its receptor Patched-1, followed by activation of Hedgehog signaling, resulting in promoting the proliferation of neighboring chondrocytes. The dual N- and C-terminal functions of BBF2H7 triggered by physiological ER stress may allow chondrocytes to simultaneously regulate distinct cellular events for differentiation and proliferation in developing cartilage.

References

Nov 14, 1996·Nature·V MarigoC J Tabin
Oct 20, 2001·Molecular and Cellular Neurosciences·J A AlbertaD H Rowitch
Dec 4, 2001·Genes & Development·P W Ingham, A P McMahon
Nov 5, 2002·Genes & Development·James K ChenPhilip A Beachy
Nov 20, 2002·The Journal of Clinical Investigation·David Ron
May 16, 2003·Nature·Henry M Kronenberg
Aug 14, 2003·Human Molecular Genetics·Clelia Tiziana StorlazziIoannis Panagopoulos
Jan 25, 2005·Nature Cell Biology·Shinichi KondoKazunori Imaizumi
Aug 19, 2005·Molecular and Cellular Biology·Ibrahim M AdhamWolfgang Engel
Jan 13, 2006·Nature Chemical Biology·Surajit Sinha, James K Chen
Dec 21, 2006·Molecular and Cellular Biology·Shinichi KondoKazunori Imaizumi
Sep 17, 2008·Genes & Development·Markku Varjosalo, Jussi Taipale
Dec 17, 2008·Developmental Cell·Jin Jiang, Chi-Chung Hui
Aug 15, 2009·Science·Chiara VecchiAntonello Pietrangelo
Sep 22, 2009·Nature Cell Biology·Tomohiko MurakamiKazunori Imaizumi
Apr 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Navin R MahadevanMaurizio Zanetti
May 4, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Emely MöllerFredrik Mertens
Jun 19, 2012·Cell Death and Differentiation·S KondoK Imaizumi

❮ Previous
Next ❯

Citations

Jan 25, 2014·Trends in Molecular Medicine·Nicolas DejeansEric Chevet
Mar 29, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sara E Patterson, Caroline N Dealy
Mar 24, 2016·Cellular and Molecular Life Sciences : CMLS·Keisuke HoriuchiHideo Morioka
Nov 13, 2015·Scientific Reports·Min CuiKazunori Imaizumi
Jun 18, 2015·Cellular and Molecular Life Sciences : CMLS·Kota Saito, Toshiaki Katada
Mar 31, 2015·Frontiers in Biology·Rebecca M Fox, Deborah J Andrew
Jan 9, 2018·Histochemistry and Cell Biology·Riko NishimuraYoshifumi Takahata
Mar 29, 2014·Birth Defects Research. Part C, Embryo Today : Reviews·Kwok Yeung TsangKathryn S E Cheah
Feb 7, 2019·Journal of Biochemistry·Kosuke Kamemura, Takahiro Chihara
Jun 20, 2014·American Journal of Physiology. Cell Physiology·Joseph E Chambers, Stefan J Marciniak
Jan 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Koji MatsuhisaKazunori Imaizumi
Jun 20, 2018·Histochemistry and Cell Biology·Janine McCaughey, David J Stephens
Jul 25, 2019·Frontiers in Cell and Developmental Biology·Luciana SampieriCecilia Alvarez
May 16, 2015·Cancer Discovery·Eric ChevetAfshin Samali
Oct 10, 2019·Cell Reports·Ethan P McCurdyUlrich Hengst
Aug 24, 2021·Frontiers in Molecular Neuroscience·Luciana SampieriCecilia Alvarez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.