PMID: 9536291Apr 16, 1998Paper

Chondrocyte tumor necrosis factor receptors and focal loss of cartilage in osteoarthritis

Osteoarthritis and Cartilage
G R WebbC J Elson

Abstract

Osteoarthritis (OA) is characterized by focal loss of cartilage. Here we show for the first time that tumor necrosis factor (TNF) alpha can act on cartilage but only at specific sites where chondrocyte TNF alpha-receptor (R) expression is high. Cartilage explants from specified sites in the knee joints of both OA patients and non-arthritic (NA) subjects were cultured with and without TNF alpha for 14 days and cumulative glycosaminoglycan (GAG) release into the supernatant measured. p55 and p75 TNF-R expression was measured by flow cytometry on chondrocytes isolated from the same sites. Cartilage explants from different sites in knee joints from both OA patients and NA subjects varied in their susceptibility to TNF alpha. Overall, the proportion of samples that responded to TNF alpha was higher in cartilage taken from OA joints than cartilage from NA subjects. Variations in p55 and p75 TNF-R expression were found between chondrocytes from different sites. p55, but not p75 TNF-R, expression on chondrocytes was closely related to the susceptibility of explants from the same site to TNF alpha-induced GAG loss. It is considered that focal loss of cartilage will occur at sites where chondrocyte p55 TNF-R expression is high, if suffic...Continue Reading

References

May 1, 1992·Immunology Today·L A Tartaglia, D V Goeddel
Jun 1, 1992·British Journal of Rheumatology·S IsmaielC J Elson
Sep 1, 1990·Annals of the Rheumatic Diseases·C I WestacottP A Dieppe
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M BrockhausH Loetscher
Aug 1, 1989·Cellular Immunology·D E YocumP Scuderi
Jul 1, 1989·The Journal of Pharmacy and Pharmacology·K ClayS Clements-Jewery
Aug 1, 1989·The Journal of Clinical Investigation·D D DeanJ F Woessner
Sep 1, 1988·Annals of the Rheumatic Diseases·F S Di GiovineG W Duff
Aug 1, 1985·Arthritis and Rheumatism·D D WoodD Hamerman
Nov 1, 1972·Journal of Biomechanics·P S Walker, J V Hajek
Jan 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M MohtaiR L Smith

❮ Previous
Next ❯

Citations

Mar 17, 2005·Rheumatology International·Tania SilvestriRiccardo Meliconi
Aug 8, 2009·Clinical Rheumatology·Jung Hoei KuHyung Lae Cho
Jun 28, 2000·Current Opinion in Clinical Nutrition and Metabolic Care·P M van der Kraan, W B van den Berg
Jan 22, 2004·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Charles J Malemud
Jul 24, 2012·Regenerative Medicine·Emma L WilliamsRichard O C Oreffo
Jun 12, 2014·In Vitro Cellular & Developmental Biology. Animal·Jiaming Xu, Changqing Zhang
Jun 7, 2006·Connective Tissue Research·Rachel E WeaverCathy J Fuller
Feb 4, 2005·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Kazuma FujimuraNatsuki Segami
Nov 13, 2003·Arthritis and Rheumatism·Hélène DumondPascale Pottie
May 12, 2000·Osteoarthritis and Cartilage·C I WestacottC J Elson
Apr 13, 2002·Osteoarthritis and Cartilage·K VuolteenahoE Moilanen
Apr 11, 2012·Journal of Tissue Engineering and Regenerative Medicine·E L WilliamsR O C Oreffo
Dec 17, 2020·Tissue Engineering. Part a·Vanessa J BianchiRita A Kandel
Aug 30, 2014·Annals of the Rheumatic Diseases·Yun-Peng ZhaoChuan-Ju Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

British Journal of Rheumatology
C J ElsonC I Westacott
Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Michelle Cameron-DonaldsonCarmelita G Frondoza
Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine
C LeyM-L Eloranta
© 2022 Meta ULC. All rights reserved