Chondrocytic cell differentiation in clear cell chondrosarcoma

Human Pathology
T AignerT Kirchner

Abstract

Clear cell chondrosarcoma is a rare mesenchymal neoplasm of unclear differentiation. Besides having a chondrogenic nature, an osteogenic differentiation was also proposed. In this study, expression analysis of extracellular matrix genes, which are specific for different mesenchymal cell differentiation pathways, were used to get a better understanding of origin and differentiation pattern of the clear cell chondrosarcoma tumor cells. Our in situ analysis of two cases shows that (1) chondrocytic cell differentiation as marked by the expression of cartilage collagen type II and proteoglycans is a characteristic feature within the development of the neoplasm, (2) multifocal chondrocyte hypertrophy as shown by the expression of type X collagen does occur, and (3) no significant expression of collagen type I, the main gene product of osteoblastic cells, is found by the neoplastic cells. Thus, our study indicates that clear cell chondrosarcoma shows a chondrogenic, but not osteogenic, differentiation and represents a true chondrosarcoma. The unusual scarcity of its extracellular and the multifocal expression of type X collagen marks clear cell chondrosarcoma as a chondrosarcoma tumor entity of a particular cell differentiation patter...Continue Reading

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Citations

Apr 7, 2000·The American Journal of Pathology·T AignerT Kirchner
Aug 8, 2001·American Journal of Clinical Pathology·S SöderT Aigner
Jul 20, 2007·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Thomas AignerChristian T Thiel
Feb 26, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Susanna MüllerThomas Aigner
Jan 12, 2000·The Journal of Pathology·T AignerT Kirchner
Sep 28, 2004·Pathology Oncology Research : POR·Joseph G Sinkovics
Dec 6, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Thomas AignerAntonio G Nascimento
Aug 10, 2000·The American Journal of Surgical Pathology·R K KalilF H Sim
Feb 28, 2006·Acta Radiologica·I LloretB Bjerkehagen
Feb 16, 2020·Der Pathologe·Albert RoessnerJohannes Haybaeck
Jun 3, 2021·Cancers·Agnieszka E ZającPiotr Rutkowski

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