Chondroid syringoma. Cytokeratin 20 immunolocalization of Merkel cells and reappraisal of apocrine folliculo-sebaceous differentiation.

Archives of Pathology & Laboratory Medicine
Mohamed E SalamaMin W Lee

Abstract

Chondroid syringoma (CS) is a benign cutaneous adnexal tumor with epithelial and stromal components. Epithelial components derived from folliculo-sebaceous-apocrine germ are evident in apocrine but not in eccrine CS. To further characterize pilosebaceous differentiation and to identify the presence of Merkel cells in the areas of follicular differentiation. Histologic type, folliculo-sebaceous differentiation, character of stroma, and presence or absence of Merkel cells by cytokeratin (CK) 20 immunoreactivity were evaluated in 25 CSs (22 apocrine and 3 eccrine) from the surgical pathology files of Henry Ford Hospital (Detroit, Mich). Most CSs occurred in the head and neck region of patients aged 40 years or older. We found no significant difference in sex, age, or location between apocrine and eccrine types. The stroma varied from myxoid (100%) to chondroid (59%), with various amounts of fat (59%) and ossification identified in 2 cases (9%) of apocrine type, but was homogeneously myxoid in the eccrine type. Follicular and sebaceous differentiation was found in 64% and 32% of apocrine CSs, respectively. Only 2 (14%) apocrine CSs with follicular differentiation were positive for CK20 (a few scattered cells in one case and numerou...Continue Reading

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Citations

Jul 1, 2011·Indian Journal of Dermatology·A S RamaswamyK Shilpa
Jun 20, 2020·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Himanshu Kumar MittalMeena Harsh
May 17, 2006·The Journal of Dermatology·Noriyuki Misago, Yutaka Narisawa
Jul 10, 2009·Journal of Cutaneous Pathology·Johanna L Baran, Mai P Hoang
Oct 30, 2009·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·Huseyin BormanAysel Colak

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