PMID: 16529337Mar 15, 2006Paper

Chondroitin product selection for the glucosamine/chondroitin arthritis intervention trial

Journal of the American Pharmacists Association : JAPhA
J G BarnhillD O Clegg

Abstract

To select a high-quality chondroitin dosage form and/or an appropriate source of sodium chondroitin for the National Institutes of Health's Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT). Controlled experimental trials. Laboratory. Not applicable. Commercially available chondroitin products were reviewed, and purified sodium chondroitin from two suppliers was evaluated through tests (infrared and near-infrared identification, moisture content, pH, optical rotation, color and clarity of aqueous solutions prepared from the powders, protein contamination, total residue following ignition and nitrogen content, determination of sodium chondroitin molecular weight, disaccharide analysis, and measurement of chondroitin, sodium, and total glycosaminoglycan content) and an onsite supplier audit. Purity, potency, and quality of sodium chondroitin powders. No commercially available chondroitin product was deemed appropriate for use in GAIT. Samples of sodium chondroitin powder from two suppliers exhibited similar disaccharide and glycosaminoglycan content. Each contained approximately 2% hyaluronic acid and 8%-9% unsulfated disaccharide. Potency was inconsistent across groups, which might have resulted from different analytic...Continue Reading

Citations

Aug 24, 2007·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Diane NykampAmy P Wenker
Sep 29, 2012·Drugs & Aging·Ryan L Ragle, Allen D Sawitzke
Jul 29, 2008·Connective Tissue Research·Fotini N Lamari
Jul 17, 2007·Journal of Pharmaceutical Sciences·Nicola Volpi
Jan 12, 2011·Rheumatic Diseases Clinics of North America·Karla L Miller, Daniel O Clegg
Dec 7, 2007·Analytical Biochemistry·Christina J MalavakiNikos K Karamanos
Sep 1, 2012·Carbohydrate Polymers·Jing HanCuiyan Wu
Sep 5, 2008·Osteoarthritis and Cartilage·M C Hochberg, D O Clegg
Jun 3, 2009·Glycobiology·M David-RaoudiJ P Pujol
Dec 1, 2010·Therapeutic Advances in Musculoskeletal Disease·Yves HenrotinCecile Lambert
Mar 11, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Johanne Martel-PelletierJean-Pierre Pelletier
Jul 31, 2009·Postgraduate Medicine·Nicholas A DiNubile

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.