Chondroitin sulfate intake inhibits the IgE-mediated allergic response by down-regulating Th2 responses in mice.

The Journal of Biological Chemistry
Shinobu SakaiToshihiko Toida

Abstract

Chondroitin sulfate (CS) was administered orally to BALB/c mice immunized intraperitoneally with ovalbumin (OVA) and/or dinitrophenylated OVA. The titers of antigen-specific IgE and IgG1 in mouse sera were determined. The antigen-specific IgE production by mice fed ad libitum with CS was significantly inhibited. We also examined the effect of feeding CS on immediate-type hypersensitivity. One hour after antigen stimulation, the ears of mice fed with CS swelled less than those of the control mice. Furthermore, the rise in serum histamine in the mice fed with CS under active systemic anaphylaxis was significantly lower than that in the controls. We next examined the pattern of cytokine production by splenocytes from mice followed by re-stimulation with OVA in vitro. The splenocytes from the mice fed with CS produced less interleukin (IL)-5, IL-10, and IL-13 than those from the control group. In contrast, the production of interferon-gamma and IL-2 by the splenocytes of mice fed with CS was not significantly different from those in the control mice. In addition, the production of transforming growth factor-beta from the splenocytes of mice fed with CS was significantly higher than that of the control mice. Furthermore, we showed t...Continue Reading

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Citations

Jun 25, 2009·Pharmacological Reviews·Hannu JärveläinenRisto Penttinen
Aug 2, 2007·Biological & Pharmaceutical Bulletin·Shuichi KusanoToshihiko Toida
Jun 29, 2012·Bioscience, Biotechnology, and Biochemistry·Shoichiro IshizakiHiroshi Akiyama
Oct 30, 2010·Biochemical and Biophysical Research Communications·Ryosuke IshikawaHajime Karasuyama
Dec 3, 2014·Metabolic Engineering·Wenqin HeMattheos Koffas
Nov 11, 2008·Analytical Biochemistry·Zhenqing ZhangRobert J Linhardt
Nov 11, 2006·Biochemical and Biophysical Research Communications·Hideki YamamotoTakashi Muramatsu
Jun 16, 2009·Journal of Cellular and Molecular Medicine·Patrick du SouichEulàlia Montell
Sep 3, 2011·Osteoarthritis and Cartilage·K BauerovaN Volpi
May 12, 2010·Journal of Agricultural and Food Chemistry·Yuji SatoReiko Teshima
Oct 14, 2019·ACS Biomaterials Science & Engineering·Lili ZhaoIstvan Toth

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