PMID: 7521953May 19, 1994Paper

Chondroitin sulfate proteoglycans protect cultured rat's cortical and hippocampal neurons from delayed cell death induced by excitatory amino acids

Neuroscience Letters
M OkamotoH Endo

Abstract

Protective effects of chondroitin sulfate proteoglycans (CSPGs) from rat's brain against delayed cell death induced by excitatory amino acids were examined in cultured neurons of the rat. CSPGs reduced delayed neuronal death induced by 10 min exposure to glutamate at a concentration between 100 microM and 1 mM when lactate dehydrogenase activity of culture medium was assayed 24 h after the exposure. CSPGs also protected neuronal death induced by 200 microM N-methyl-D-aspartate (NMDA), kainate or 100 microM alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA). CSPGs reduced death of cortical and hippocampal neurons even when they were administered at 2 h, but not 6 and 12 h, after the exposure to glutamate. These results indicate that CSPGs may have a neuroprotective action against acute noxious conditions in the brain.

References

Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M C KieferP J Barr
Jan 1, 1990·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M P Mattson, B Rychlik
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Citations

Sep 1, 2005·Acta Neuropathologica·Shabnam BaigSeth Love
Nov 19, 2014·Molecular Neurobiology·Anne SuttkusThomas Arendt
Jul 5, 2019·Brain and Behavior·Josef HeusingerRobert-Benjamin Illing
Nov 21, 2014·The European Journal of Neuroscience·J YamadaS Jinno
Sep 22, 2007·The Journal of Pharmacology and Experimental Therapeutics·Noelia CañasManuela G López
Aug 2, 2020·The European Journal of Neuroscience·Sophie SchmidtMarkus Morawski
Sep 12, 2006·Trends in Molecular Medicine·Mariano S Viapiano, Russell T Matthews

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