Chondroprotective effects of taurine in primary cultures of human articular chondrocytes

The Tohoku Journal of Experimental Medicine
Qin LiuLi Zheng

Abstract

Articular cartilage is characterized by the lack of blood vessels and has a poor self-healing potential. Limited cell numbers and dedifferentiation of chondrocytes when expanded in vitro are the major obstacles of autologous chondrocyte implantation. Autologous chondrocyte implantation is a cell-based treatment that can be used as a second-line measure to regenerate chondral or osteochondral defects in younger, active patients. There is an urgent need to find an effective chondrogenic protection agent alleviating or inhibiting chondrocyte dedifferentiation. In this study, we explored the effect of taurine (2-aminoethane sulfonic acid) on proliferation and phenotype maintenance of human articular chondrocytes by analyzing the cell proliferation, morphology, viability, and expression of cartilage specific mRNAs and proteins. Primary chondrocytes were isolated from human articular cartilage tissues. Results showed that taurine effectively promoted chondrocyte growth and enhanced accumulation of glycosaminoglycans and collagens in the conditioned media of chondrocytes. Moreover, taurine exposure caused significant increases in the relative expression levels of mRNAs for cartilage specific markers, including aggrecan, collagen type ...Continue Reading

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Citations

Jan 10, 2018·Inflammopharmacology·Chandrasekaran Chinampudur VelusamiBharathi Bethapudi
Mar 2, 2018·Redox Report : Communications in Free Radical Research·Yiqun BianShui Sun
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Jan 3, 2018·International Journal of Molecular Sciences·Sara CheleschiAntonella Fioravanti
Jun 3, 2021·Journal of Personalized Medicine·Mohammed MashyakhyShankargouda Patil

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