Choosing Important Health Outcomes for Comparative Effectiveness Research: An Updated Review and User Survey

PloS One
Sarah L GorstPaula R Williamson

Abstract

A COS represents an agreed minimum set of outcomes that should be measured and reported in all trials of a specific condition. The COMET (Core Outcome Measures in Effectiveness Trials) initiative aims to collate and stimulate the development and application of COS, by including data on relevant studies within a publically available internet-based resource. In recent years, there has been an interest in increasing the development of COS. Therefore, this study aimed to provide an update of a previous review, and examine the quality of development of COS. A further aim was to understand the reasons why individuals are searching the COMET database. A multi-faceted search strategy was followed, in order to identify studies that sought to determine which outcomes/domains to measure in clinical trials of a specific condition. Additionally, a pop up survey was added to the COMET website, to ascertain why people were searching the COMET database. Thirty-two reports relating to 29 studies were eligible for inclusion in the review. There has been an improvement in the description of the scope of a COS and an increase in the proportion of studies using literature/systematic reviews and the Delphi technique. Clinical experts continue to be ...Continue Reading

References

Jun 16, 2009·Lancet·Iain Chalmers, Paul Glasziou
Nov 26, 2009·Obstetrics and Gynecology·Iain Chalmers, Paul Glasziou
Aug 8, 2012·Trials·Paula R WilliamsonPeter Tugwell
Jan 15, 2014·Lancet·Malcolm R MacleodPaul Glasziou
Jul 12, 2014·Trials·Elizabeth GargonMike Clarke
Aug 25, 2015·Trials·Jamie J KirkhamUNKNOWN COS-STAR Group
Nov 1, 2014·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·E GargonP Williamson

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Citations

Mar 28, 2017·BJU International·Steven MacLennanUNKNOWN COMPACTERS Study Group
Mar 28, 2017·Journal of Clinical Epidemiology·Karen L BarnesPaula R Williamson
Feb 2, 2017·Journal of Clinical Epidemiology·Hayet AmeurAgnes Dechartres
Feb 28, 2017·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nicole EvangelidisUNKNOWN Standardized Outcomes in Nephrology–Hemodialysis (SONG-HD) Initiative
Apr 6, 2018·PloS One·Youri YordanovPhilippe Ravaud
Feb 15, 2018·The British Journal of Dermatology·J KottnerUNKNOWN International Cochrane Skin Group Core Outcome Set Initiative (CSG-COUSIN) group
Nov 18, 2017·PLoS Medicine·Jamie J KirkhamPaula R Williamson
Apr 20, 2017·BJOG : an International Journal of Obstetrics and Gynaecology·Jmn DuffyUNKNOWN International Collaboration to Harmonise Outcomes in Pre-eclampsia (iHOPE)
Dec 19, 2017·The Clinical Journal of Pain·Svjetlana DosenovicLivia Puljak
Mar 2, 2016·Journal of Comparative Effectiveness Research·Sean R TunisPaula R Williamson
Jun 20, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·S MeherZ Alfirevic
Apr 20, 2019·The British Journal of Dermatology·D M ThiboutotJ Tan
May 6, 2019·Aesthetic Surgery Journal·Yusuf HassanMatthew C McRae
Jan 17, 2019·The Journal of Rheumatology·Toby O SmithPhilip G Conaghan
Dec 14, 2019·Research Synthesis Methods·Ginny BruntonChris Gale
Aug 3, 2017·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Karine E ManeraUNKNOWN SONG-PD Investigators
Jul 2, 2017·Archives of Disease in Childhood. Education and Practice Edition·James WebbeChris Gale
Sep 10, 2019·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Pim Cuijpers
Jul 2, 2020·British Journal of Health Psychology·Karen Matvienko-SikarMolly Byrne
Jul 22, 2018·Pilot and Feasibility Studies·Evan Mayo-WilsonKay Dickersin
May 16, 2020·British Journal of Haematology·Ursula RochauReinhard Stauder
Mar 14, 2017·Annals of Surgery·Kerry N L AveryUNKNOWN CONSENSUS Esophageal Cancer Working Group
Oct 31, 2019·Aesthetic Plastic Surgery·Anders TolstrupJacob Rosenberg
Jul 7, 2017·Trials·Paula R WilliamsonBridget Young

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Software Mentioned

COS
COMET
Ovid

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