Nov 26, 2019

Chordoma of the Clivus and Acute Myeloid Leukemia: Is There a Connection?

Journal of Pediatric Hematology/oncology
Trisha LarkinBiljana Horn

Abstract

Chordoma is a rare cancer in children and understanding the genesis of this tumor may contribute to treatment approaches. Evidence has proposed VDC/IE (vincristine, doxorubicin, cyclophosphamide/ifosfamide, etoposide) as a treatment option for young patients with chordoma to avoid the long-term effects of radiation therapy. We present a case of acute myeloid leukemia developing during treatment of localized chordoma of the clivus in a 20-month-old male. We propose a genomic relationship that may have contributed to the development of clival chordoma and acute myeloid leukemia without a latency period and advocate for genomic sequencing in children with chordoma before the initiation of systemic therapies.

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Mentioned in this Paper

Doxorubicin
Genome
Etoposide
Neoplasms
Chordoma
Therapeutic Radiology Procedure
Cerebellar Declive
Malignant Neoplasms
Chordoma of Clivus
Carcinogenesis

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