Chordomas at High Prevalence in the Captive Population of the Endangered Perdido Key Beach Mouse (Peromyscus polionotus trissyllepsis)

Veterinary Pathology
K R TaylorJ R Abbott

Abstract

The Perdido Key beach mouse (Peromyscus polionotus trissyllepsis) is a critically endangered subspecies of the oldfield mouse. The captive population, currently maintained by 3 Florida zoos, is entirely derived from just 3 wild-caught ancestor mice. Necropsy and histopathology revealed chordoma of the vertebral column in 38 of 88 (43%) mice. The tumors were locally expansile and invasive masses of large physaliferous (vacuolated) cells with small, round, hyperchromatic nuclei, similar to the "classic" form of chordomas described in humans. Primary tumors rarely contained small amounts of bone and cartilaginous matrix, characteristic of the "chondroid" form. Neoplastic cells contained abundant granules positive by the periodic acid-Schiff reaction. Brachyury and cytokeratin AE1/AE3 were detected in neoplastic cells by immunohistochemistry, but uncoupling protein 1 was not identified. Primary tumors occurred along the entire vertebral column-cervical, 5 of 38 (13%); thoracic, 16 (42%); lumbar, 13 (34%); and sacral, 10 (26%)-and 10 (26%) mice had multiple primary masses. Metastases to the lungs were noted in 13 of the 38 (34%) mice. Mice diagnosed with chordomas postmortem ranged from 424 to 2170 days old, with a mean of 1399 days...Continue Reading

References

Jan 1, 1991·Toxicologic Pathology·G M Zwicker, R C Eyster
Jan 1, 1988·Veterinary Pathology·S A StefanskiH D Giles
Aug 1, 1973·Cancer·M J HeffelfingerJ W Beabout
Nov 1, 1967·Cancer·N L HiginbothamH O Hustu
Sep 1, 1984·Veterinary Pathology·W J Hadlow
Mar 1, 1983·The American Journal of Surgical Pathology·R Volpe, A Mazabraud
Sep 1, 1980·Veterinary Pathology·G L Coleman
Mar 1, 1993·Veterinary Pathology·B H WilliamsD G Dunn
Feb 25, 1998·American Journal of Medical Genetics·J StepanekR L Rubenstein
Jul 7, 2000·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·G W PyeS P Terrell
Mar 3, 2001·Cancer Causes & Control : CCC·M L McMasterD M Parry
May 9, 2003·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·John S MundayRaul Weiss
Sep 25, 2003·International Journal of Cancer. Journal International Du Cancer·Paola RivaLidia Larizza
Oct 6, 2004·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·John S MundayLauren J Richey
Apr 9, 2005·International Journal of Cancer. Journal International Du Cancer·Xiaohong ' Rose ' YangAlisa M Goldstein
Apr 1, 2008·Journal of Comparative Pathology·G H WooK Doi
Sep 9, 2008·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Antonio CarminatoFranco Mutinelli
Nov 28, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kyung-Suk ChoiBrian D Harfe
Apr 24, 2009·Toxicologic Pathology·Richard H BrunerGeorge A Parker
Oct 6, 2009·Nature Genetics·Xiaohong R YangMichael J Kelley
Jul 31, 2010·Archives of Pathology & Laboratory Medicine·Nirmala A JambhekarAjay Puri
Aug 10, 2011·Laboratory animal research·Eun-Sang ChoHwa-Young Son
Oct 25, 2011·Acta Veterinaria Scandinavica·Øyvind StigenCaroline P Åkesson
Sep 1, 2009·Journal of Toxicologic Pathology·Akiko AnagawaYuji Oishi
Oct 16, 2012·Nature Genetics·Nischalan PillayAdrienne M Flanagan
Oct 16, 2013·Journal of Cancer Research and Therapeutics·Giovanni ConzoLuigi Santini
Dec 7, 2013·Disease Models & Mechanisms·Alexa BurgerDaniel A Haber
Jun 11, 2014·Veterinary Pathology·T K CooperJ M Spitsbergen

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Citations

Jul 5, 2016·Seminars in Cell & Developmental Biology·Amanda HavighorstHippokratis Kiaris
Dec 14, 2018·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Lucile SautierThomas M Donnelly
Dec 17, 2019·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Jordan E ColeAndrew Cartoceti

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