Chordomas of the Skull Base, Mobile Spine, and Sacrum: An Epidemiologic Investigation of Presentation, Treatment, and Survival

World Neurosurgery
Scott L ZuckermanIlya Laufer

Abstract

Chordomas are rare primary bone tumors that arise from the axial skeleton. Our objective was to analyze trends in radiation and surgery over time and determine location-based survival predictors for chordomas of the skull base, mobile spine, and sacrum. A retrospective cohort study of the SEER (Surveillance Epidemiology and End Results) database from 1973 to 2013 was conducted. All patients had histologically confirmed chordomas. The principal outcome measure was overall survival (OS). The cohort included 1616 patients: skull base (664), mobile spine (444), and sacrum (508). Skull base tumors presented earliest in life (47.4 years) and sacral tumors presented latest (62.7 years). Rates of radiation remained stable for skull base and mobile spine tumors but declined for sacral tumors (P = 0.006). Rates of surgical resection remained stable for skull base and sacral tumors but declined for mobile spine tumors (P = 0.046). Skull base chordomas had the longest median survival (162 months) compared with mobile spine (94 months) and sacral tumors (87 months). Being married was independently associated with improved OS for skull base tumors (hazard ratio, 0.73; 95% confidence interval, 0.53-0.99; P = 0.044). Surgical resection was ind...Continue Reading

Citations

Jun 19, 2019·Journal of Orthopaedic Surgery and Research·Jin-Feng HuangAi-Min Wu
Sep 18, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yusuke DemizuUNKNOWN Japan Carbon-Ion Radiation Oncology Study Group
Apr 17, 2020·World Neurosurgery·Brooke T KennamerIman Feiz-Erfan
Jan 12, 2020·World Neurosurgery·Ke WangZhen Wu
Feb 17, 2021·The Spine Journal : Official Journal of the North American Spine Society·Zach PenningtonDaniel M Sciubba
Apr 2, 2020·World Neurosurgery·Samuel VieiraThiago Albonette-Felicio

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