PMID: 12764042May 24, 2003Paper

Choreography of early thalamocortical development

Cerebral Cortex
Z MolnárGuillermina López-Bendito

Abstract

Thalamic axons, which carry most of the information from the sensory environment, are amongst the first projections to reach the cerebral cortex during embryonic development. It has been proposed that the scaffold of early generated cells in the ventral thalamus, internal capsule and preplate play a pivotal role in their deployment through sharp gene expression boundaries. These ideas were recently evaluated in various strains of mutant mice. In Tbr1, Gbx2, Pax6 KO both thalamic and corticofugal projections fail to traverse the striatocortical junction. In both Emx2 and Pax6 KO brains, the misrouted thalamic afferents are accompanied by displacements of the pioneering projections from the internal capsule. Regardless of their altered route, thalamic afferents in the reeler and L1 KO mice seem to be able to redistribute themselves on the cortical sheet and establish normal periphery-related representation in the somatosensory cortex. Early neural activity delivered through the thalamic projections is thought to be involved in the realignment process of thalamic axons at the time of their accumulation in the subplate layer. However, axonal growth and the early topographic arrangement of thalamocortical fiber pathways appear norma...Continue Reading

Citations

Mar 1, 2006·Experimental Brain Research·Cecilia P MargretRobert S Waters
Jan 29, 2013·European Journal of Medicinal Chemistry·Julio BenítezDinorah Gambino
Mar 22, 2005·Nature Neuroscience·Fadel TissirAndre M Goffinet
Jul 30, 2008·Cerebral Cortex·Marat MinlebaevRoustem Khazipov
Apr 8, 2009·Cerebral Cortex·Libing ZhouAndre M Goffinet
Jun 26, 2010·Cerebral Cortex·Galina P DemyanenkoPatricia F Maness
Feb 1, 2012·Neural Development·Catherine A DyeKelly J Huffman
May 1, 2009·PLoS Biology·Graham E LittleKevin J Mitchell
Apr 19, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Achira RoyShubha Tole
May 10, 2005·Proceedings of the National Academy of Sciences of the United States of America·Todd T Kroll, Dennis D M O'Leary
Apr 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·María PedrazaJuan A De Carlos
Feb 15, 2014·Clinics in Perinatology·Nora TusorA David Edwards
May 23, 2006·Clinical Genetics·A M HeverV van Heyningen
Oct 24, 2007·The European Journal of Neuroscience·Nicole ChabotGilles Bronchti
Mar 8, 2006·The European Journal of Neuroscience·David J PriceZoltán Molnár
Dec 15, 2012·Developmental Neurobiology·Christian Alfano, Michèle Studer
May 23, 2012·The European Journal of Neuroscience·Zoltán MolnárDavid J Price
May 23, 2012·The European Journal of Neuroscience·Esmee S B van KleefAlexandre Bonnin
May 23, 2012·The European Journal of Neuroscience·Reha S Erzurumlu, Patricia Gaspar
Jan 18, 2015·Cerebral Cortex·Gareth BallSerena J Counsell
Aug 28, 2004·Trends in Neurosciences·Sonia Garel, John L R Rubenstein
May 6, 2004·Brain Research. Developmental Brain Research·Oscar Rios, Julio Villalobos
Sep 11, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Gareth BallSerena J Counsell
Jan 1, 2008·Cell Adhesion & Migration·Tina Rüdiger, Jürgen Bolz
Dec 17, 2014·Trends in Neurosciences·Barbara L Finlay, Ryutaro Uchiyama
Mar 8, 2006·Reviews in the Neurosciences·Francisco AboitizRicardo R García
Oct 12, 2007·Physiological Reviews·Yehezkel Ben-AriRustem Khazipov
May 16, 2018·The European Journal of Neuroscience·Guela SokhadzeWilliam Guido
Apr 30, 2019·Wiley Interdisciplinary Reviews. Developmental Biology·Yasushi Nakagawa

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