Chorioamnionitis with or without funisitis increases the risk of hypotension in very low birthweight infants on the first postnatal day but not later.

Archives of Disease in Childhood. Fetal and Neonatal Edition
S Y R LeeV Y H Yu

Abstract

To evaluate the relation between chorioamnionitis and hypotension in very low birthweight infants. Retrospective cohort study in infants with a birth weight of <1500 g born between January 2002 and September 2004. The placentas were examined for evidence of chorioamnionitis and funisitis. Hypotension was defined by the use of vasopressors. Of 105 infants, 37 (35%) were chorioamnionitis positive. The onset of hypotension had a skewed distribution: day 1 for 30 episodes and scattered from day 2 to day 19 for the remaining 22. Of the 30 infants who developed hypotension on day 1, 17 (57%) were chorioamnionitis positive. The mean maturity of the chorioamnionitis positive group was 27.91 weeks, marginally less than the mean maturity of 29.05 weeks of the chorioamnionitis negative group (p = 0.05). After adjustment of the effects for confounding variables (birth weight, gestation, surfactant therapy, mechanical ventilation on day 1, high frequency oscillatory ventilation, patent ductus arteriosus), chorioamnionitis was the significant factor in line with hypotension developing on day 1 (adjusted odds ratio 5.14, 95% confidence interval 1.51 to 17.50). There was no evidence that hypotension developing after day 1 was associated with c...Continue Reading

References

Oct 1, 1987·Archives of Disease in Childhood·V M Miall-AllenA G Whitelaw
Feb 24, 2000·Journal of Perinatology : Official Journal of the California Perinatal Association·S DemariniE F Donovan
Feb 13, 2001·Seminars in Neonatology : SN·I Seri
Sep 6, 2001·Journal of Perinatology : Official Journal of the California Perinatal Association·I Al-AweelD K Richardson
Feb 19, 2002·American Journal of Respiratory and Critical Care Medicine·Boris W KramerAlan H Jobe
Oct 17, 2002·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·P PacoraR Romero
Apr 2, 2003·Seminars in Neonatology : SN·Alan H Jobe
Mar 6, 2004·Seminars in Neonatology : SN·Nimish V Subhedar
Mar 26, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Toby Debra YanowitzBeverly Sobchak Brozanski
Dec 3, 2004·Pediatrics·Michael J MunroCharles P Barfield

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Citations

Oct 12, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·M GantertB W Kramer
Feb 15, 2014·Clinics in Perinatology·Vann ChauSteven P Miller
Oct 22, 2010·The Journal of Pediatrics·Leonora HendsonThierry Lacaze-Masmonteil
Sep 11, 2009·Annals of Neurology·Vann ChauSteven P Miller
Feb 3, 2009·American Journal of Obstetrics and Gynecology·Humberto AzpuruaCatalin S Buhimschi
Dec 23, 2017·American Journal of Reproductive Immunology : AJRI·Shelley M Lawrence, James L Wynn
Jan 24, 2016·Neonatal Network : NN·Sandra L Shead
May 26, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Shing Yan Robert Lee, Chi Wai Leung
Aug 24, 2021·American Journal of Hypertension·J LongN T Mueller

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