Choriocapillaris and choroidal microvasculature imaging with ultrahigh speed OCT angiography

PloS One
Woojhon ChoiJames G Fujimoto

Abstract

We demonstrate in vivo choriocapillaris and choroidal microvasculature imaging in normal human subjects using optical coherence tomography (OCT). An ultrahigh speed swept source OCT prototype at 1060 nm wavelengths with a 400 kHz A-scan rate is developed for three-dimensional ultrahigh speed imaging of the posterior eye. OCT angiography is used to image three-dimensional vascular structure without the need for exogenous fluorophores by detecting erythrocyte motion contrast between OCT intensity cross-sectional images acquired rapidly and repeatedly from the same location on the retina. En face OCT angiograms of the choriocapillaris and choroidal vasculature are visualized by acquiring cross-sectional OCT angiograms volumetrically via raster scanning and segmenting the three-dimensional angiographic data at multiple depths below the retinal pigment epithelium (RPE). Fine microvasculature of the choriocapillaris, as well as tightly packed networks of feeding arterioles and draining venules, can be visualized at different en face depths. Panoramic ultra-wide field stitched OCT angiograms of the choriocapillaris spanning ∼32 mm on the retina show distinct vascular structures at different fundus locations. Isolated smaller fields at...Continue Reading

References

Jan 1, 1988·Eye·J P SarksM C Killingsworth
Jul 1, 1989·International Ophthalmology·A W FryczkowskiJ Walker
May 1, 1987·Archives of Ophthalmology·S Yoneya, M O Tso
Feb 1, 1963·Archives of Ophthalmology·E FRIEDMANT KUWABARA
Aug 25, 2004·Investigative Ophthalmology & Visual Science·Imre LengyelGlen Jeffery
Jul 3, 2008·Optics Letters·Adrian MariampillaiVictor X D Yang
Jul 22, 2008·American Journal of Ophthalmology·Richard F SpaideMaria C Pozonni
Apr 10, 2009·Investigative Ophthalmology & Visual Science·D Scott McLeodGerard A Lutty
Aug 21, 2006·Optics Express·Shuichi MakitaYoshiaki Yasuno
Mar 10, 2010·Journal of Biomedical Optics·Lingfeng Yu, Zhongping Chen
Mar 15, 2011·Investigative Ophthalmology & Visual Science·Robert F MullinsJian Huang
Mar 14, 2012·Investigative Ophthalmology & Visual Science·Reza MotaghiannezamScott E Fraser
Aug 17, 2012·Journal of Biomedical Optics·Cedric BlatterRainer A Leitgeb
Jan 11, 2013·Biomedical Optics Express·Boy BraafJohannes F de Boer

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Citations

Feb 16, 2016·Ophthalmic Surgery, Lasers & Imaging Retina·Talisa E de CarloElias Reichel
Oct 21, 2015·Progress in Retinal and Eye Research·Daniela FerraraJay S Duker
Jan 10, 2016·American Journal of Ophthalmology·Wilfried MinvielleEric H Souied
Apr 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yali JiaDavid Huang
Dec 20, 2015·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·P P FangF G Holz
Dec 24, 2015·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·P P FangF G Holz
Nov 26, 2014·Ophthalmic Surgery, Lasers & Imaging Retina·Eric MoultJames G Fujimoto
Nov 26, 2015·Ophthalmic Surgery, Lasers & Imaging Retina·Alexander H de Castro-AbegerCaroline R Baumal
Oct 8, 2014·Ophthalmic Surgery, Lasers & Imaging Retina·Mariana R ThorellPhilip J Rosenfeld
Nov 26, 2015·Journal of Lightwave Technology : a Joint IEEE/OSA Publication·Demis D JohnVijaysekhar Jayaraman
Mar 22, 2015·Ophthalmology·Talisa E de CarloNadia K Waheed
Jul 3, 2015·Biomedical Optics Express·Jan Philip KolbRobert Huber
May 14, 2016·Expert Review of Medical Devices·Rupesh AgrawalAniruddha Agarwal
Dec 4, 2015·Journal of Ophthalmology·Eliana CostanzoEric H Souied
Oct 21, 2016·Ophthalmic Surgery, Lasers & Imaging Retina·Ricardo Noguera LouzadaCaroline R Baumal
Nov 15, 2016·Ophthalmic Surgery, Lasers & Imaging Retina·Haiyan WangHui Cao
Jan 31, 2017·Genes·Jesse D SengilloStephen H Tsang
Jun 12, 2017·Vision Research·Peter L NesperAmani A Fawzi
Mar 16, 2017·International Journal of Retina and Vitreous·Jose Mauricio Botto de Barros GarciaMarcos Avila
Apr 25, 2017·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·João Paulo CunhaAntónio Castanheira-Dinis
Mar 17, 2017·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Emily Wright MayesThomas R Hedges
Jun 6, 2017·Ophthalmology and Eye Diseases·Jeffrey MaDimitra Skondra
Nov 16, 2018·PloS One·Marco NassisiSrinivas R Sadda
Mar 13, 2019·European Journal of Ophthalmology·José Ignacio Fernández-VigoJosé Ángel Fernández-Vigo
Apr 6, 2019·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Hosein Hoseini-YazdiScott A Read

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Methods Mentioned

BETA
light scattering

Software Mentioned

SSOCT
SDOCT

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