Choriocapillaris changes in dry age-related macular degeneration and geographic atrophy: a review

Eye and Vision
Malvika AryaNadia K Waheed

Abstract

Age-related macular degeneration (AMD) is a leading cause of central vision loss worldwide. The progression of dry AMD from early to intermediate stages is primarily characterized by increasing drusen formation and adverse impact on outer retinal cells. Late stage AMD consists of either geographic atrophy (GA), the non-exudative (dry) AMD subtype, or choroidal neovascularization, the exudative (wet) AMD subtype. GA is characterized by outer retinal and choroidal atrophy, specifically the photoreceptor layer, RPE, and choriocapillaris. Much remains to be discovered regarding the pathogenesis of AMD progression and subsequent development of GA. As the functionality of all three layers is closely linked, the temporal sequence of events that end up in atrophy is important in the understanding of the pathogenic pathway of the disease. The advent of OCTA, and particularly of swept-source technology, has allowed for depth-resolved imaging of retinal vasculature and the choriocapillaris. With the use of OCTA, recent studies demonstrate that choriocapillaris flow alterations are closely associated with the development and progression of AMD. Such changes may even possibly offer predictive value in determining progression of GA. This art...Continue Reading

References

Jun 1, 1992·Ophthalmology·R KleinK L Linton
Jan 1, 1988·Eye·J P SarksM C Killingsworth
Aug 27, 2003·Investigative Ophthalmology & Visual Science·Redmer van LeeuwenPaulus T V M de Jong
Apr 14, 2004·Archives of Ophthalmology·Nathan CongdonUNKNOWN Eye Diseases Prevalence Research Group
Jul 6, 2004·Ophthalmology·Sandra C TomanyPaulus T V M De Jong
Aug 25, 2004·Investigative Ophthalmology & Visual Science·Imre LengyelGlen Jeffery
Mar 12, 2005·Science·Albert O EdwardsLindsay A Farrer
Jan 25, 2006·Investigative Ophthalmology & Visual Science·Diego G Espinosa-HeidmannScott W Cousins
Feb 7, 2006·Ophthalmology·Johanna M SeddonRon A Adelman
May 20, 2008·Investigative Ophthalmology & Visual Science·Monika FleckensteinFrank G Holz
Apr 10, 2009·Investigative Ophthalmology & Visual Science·D Scott McLeodGerard A Lutty
Jan 12, 2011·Archives of Ophthalmology·Ronald KleinJinan B Saaddine
Mar 15, 2011·Investigative Ophthalmology & Visual Science·Robert F MullinsJian Huang
Apr 19, 2011·Investigative Ophthalmology & Visual Science·Steffen Schmitz-ValckenbergUNKNOWN Geographic Atrophy Progression (GAP) Study Group
Jul 7, 2011·Experimental Eye Research·Robert F MullinsEdwin M Stone
Mar 15, 2014·JAMA Ophthalmology·Alan C BirdGregory S Hageman
Jun 14, 2014·Neurobiology of Aging·Antje BiesemeierUlrich Schraermeyer
Nov 26, 2014·Ophthalmic Surgery, Lasers & Imaging Retina·Eric MoultJames G Fujimoto
Nov 26, 2014·Ophthalmic Surgery, Lasers & Imaging Retina·Douglas MatsunagaAmir H Kashani
Dec 9, 2014·Progress in Retinal and Eye Research·S Scott WhitmoreRobert F Mullins
Apr 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yali JiaDavid Huang
May 15, 2015·Ophthalmology·Moritz LindnerUNKNOWN Fundus Autofluorescence in Age-Related Macular Degeneration Study Group
Sep 15, 2015·Experimental Eye Research·Kathleen R ChircoRobert F Mullins
Oct 21, 2015·Progress in Retinal and Eye Research·Daniela FerraraJay S Duker
Dec 19, 2015·Ophthalmology·Ebenezer DanielUNKNOWN Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) Research Group
Feb 13, 2016·Ophthalmic Research·Patrick KaszubskiR Theodore Smith
Mar 31, 2016·Developments in Ophthalmology·Nadia K WaheedPhilip J Rosenfeld
Oct 27, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Florian AltenNicole Eter
Jul 28, 2016·Ophthalmology·Marco PellegriniGiovanni Staurenghi

❮ Previous
Next ❯

Citations

Nov 6, 2018·Clinical & Experimental Ophthalmology·Jiwon BaekWon Ki Lee
Oct 8, 2019·Ophthalmic Surgery, Lasers & Imaging Retina·Nicholas T RinellaDaniel M Schwartz
Jul 3, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Marco NassisiSrinivas R Sadda
May 9, 2019·Biomedical Optics Express·Tristan T HormelYali Jia
Apr 17, 2020·International Journal of Molecular Sciences·Céline KosterArthur A Bergen
Oct 3, 2020·Translational Biophotonics·Yan LiZhongping Chen
Aug 25, 2020·Translational Vision Science & Technology·Benjamin K YoungRon A Adelman
Jul 16, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Liran TiosanoSrinivas R Sadda
Nov 7, 2019·Scientific Reports·Marijana SamardzijaChristian Grimm
Nov 12, 2020·Translational Vision Science & Technology·Janan ArslanPaul N Baird
Jan 29, 2020·Progress in Retinal and Eye Research·Alon HarrisJulia Arciero
Apr 29, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hyun Goo KangChristopher Seungkyu Lee
Jun 12, 2021·Acta Ophthalmologica·Amisha SanghaniCynthia Yu-Wai-Man
Aug 14, 2021·Clinical & Experimental Ophthalmology·Danny Siu-Chun NgTimothy Y Y Lai
Aug 27, 2021·American Journal of Ophthalmology·Nicholas T RinellaJacque L Duncan
Aug 11, 2020·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Philipp L MüllerFrank G Holz
Dec 10, 2021·European Journal of Ophthalmology·Francisco de Asís Bartol-PuyalLuis Pablo

❮ Previous
Next ❯

Methods Mentioned

BETA
electron microscopy
imaging technique
imaging techniques

Software Mentioned

OCTA
VISTA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Advances in Experimental Medicine and Biology
Ema OzakiPeter Humphries
Ophthalmology
Maureen G MaguireComplications of Age-related Macular Degeneration Prevention Trial (CAPT) Research Group
Journal of Clinical Medicine
Lucia CelkovaMatthew Campbell
© 2022 Meta ULC. All rights reserved