Choriocapillaris flow impairment surrounding geographic atrophy correlates with disease progression

PloS One
Marco NassisiSriniVas R Sadda

Abstract

To evaluate the correlation between the choriocapillaris (CC) flow alterations around geographic atrophy (GA) and the GA yearly growth rate (yGR) in patients with dry age-related macular degeneration (AMD). We retrospectively reviewed and analyzed spectral domain optical coherence tomography (SD-OCT) and SD-OCT angiography images of consecutive patients with GA acquired using the Cirrus OCT at the Doheny Eye Centers between 2015 and 2017. All eligible patients had one 6 x 6 mm OCTA scan acquired during the first visit (considered as baseline) and two fovea-centered 512 x 128 macular cubes (6 x 6 mm) acquired at baseline and after a minimum of 12 months. The fundus images from the OCT volumes were used to manually delineate the GA area and calculate the yGR after square root transformation. The en-face angiogram at the level of the CC was analyzed for the percentage of flow voids (FV) outside the atrophic lesion (FVOUT) and in the para- and peri-atrophy regions (FV500 and FV1000 respectively; two concentric 500 μm wide rings around the atrophy edge). These values, together with the difference between FV500 and FV1000 (ΔFV), were then correlated with the corresponding yGR. Thirty-three eyes of 23 patients were eligible for the an...Continue Reading

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Citations

Feb 12, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ahmed Roshdy AlagorieSrinivas R Sadda
Dec 6, 2019·JAMA Ophthalmology·David Sarraf, Srinivas Sadda
Feb 27, 2020·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Thomas J HeesterbeekAnneke I den Hollander
Mar 8, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Li SuSriniVas R Sadda
Aug 25, 2020·Translational Vision Science & Technology·Yong Sok JiSriniVas R Sadda
Oct 6, 2020·Biomedical Optics Express·Yue YuJames G Fujimoto
Jul 16, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Liran TiosanoSrinivas R Sadda
Aug 29, 2020·Translational Vision Science & Technology·Phillip X BraunNadia K Waheed
Oct 14, 2020·Eye·Federico CorviSrinivas R Sadda
Mar 24, 2020·The British Journal of Ophthalmology·Riccardo SacconiGiuseppe Querques
Jan 1, 2021·Progress in Retinal and Eye Research·Andrew P VoigtRobert F Mullins
Mar 7, 2021·Journal of Clinical Medicine·Jackson ScharfDavid Sarraf
Jul 23, 2021·Progress in Retinal and Eye Research·Raphael LejoyeuxJay Chhablani
Aug 11, 2020·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Philipp L MüllerFrank G Holz
Sep 26, 2021·Retina·Riccardo SacconiGiuseppe Querques

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Methods Mentioned

BETA
electron microscopy
imaging techniques

Software Mentioned

SPSS Statistics
ImageJ

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