Choriocarcinoma and epithelial trophoblastic tumor: successful treatment of relapse with hysterectomy and high-dose chemotherapy with peripheral stem cell support: a case report

Gynecologic Oncology
Stacey KnoxDonald P Goldstein

Abstract

Post-termchoriocarcinoma is a rare complication of pregnancy. The presence of epithelioid trophoblastic elements may lead to the persistence of locally invasive disease which is unresponsive to multiagent chemotherapy. Relapse is associated with an estimated mortality rate of 30%. We present a case of Stage IC post-term choriocarcinoma and epithelioid trophoblastic tumor. While the metastatic sites in the lungs responded to multiagent chemotherapy, a hysterectomy was required to treat persistent disease in the uterus. The patient relapsed within 4 months of completion of chemotherapy. Relapse was treated with high-dose chemotherapy with peripheral stem cell support. The patient is alive with no evidence of disease 23 months posttransplant. The application of multimodality treatment and high-dose chemotherapy resulted in a successful outcome for this patient, indicating a potential role for high-dose therapy in patients who suffer a relapse of choriocarcinoma.

Citations

May 6, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J WangM J Seckl
Dec 5, 2006·Journal of Clinical Pathology·P M L H VenckenR P Zweemer
Feb 18, 2014·Current Obstetrics and Gynecology Reports·Siew-Fei Ngu, Karen K L Chan
Jan 23, 2016·Gynecologic Oncology Reports·Yuko ImamuraHidetaka Katabuchi
Jun 21, 2007·The Journal of Obstetrics and Gynaecology Research·Satoshi UrabeYoshiki Kudo
Jul 9, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Xiaoyan ShenYu Xiao
Aug 24, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Xiaofei ZhangBingjian Lü
Oct 16, 2004·Current Oncology Reports·Naveed SarwarMichael J Seckl
Nov 1, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Oluwole FadarePei Hui
Mar 14, 2013·Korean Journal of Pathology·Woo Jung SungMi Jin Kim
Jul 15, 2017·Journal of Pharmacology & Pharmacotherapeutics·Sahoo AshokkumarVikram Kate
Nov 28, 2018·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Stephanie M McGregorRicardo R Lastra
Dec 3, 2015·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Bingjian LuYun Liang
Jun 26, 2003·Archives of Pathology & Laboratory Medicine·Dan-Hua ShenAnnie N Y Cheung
Dec 8, 2006·Archives of Pathology & Laboratory Medicine·Kimberly H AllisonRochelle L Garcia
Nov 15, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·Annie Nga-Yin Cheung

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