Choriocarcinoma: blocking factor and monoclonal antibody iodine 131 imaging

American Journal of Obstetrics and Gynecology
R A PattilloR F Mattingly

Abstract

Postoperative iodine 131 monoclonal antibody localization in metastatic choriocarcinoma was accomplished in this study. The monoclonal antibody was prepared to male choriocarcinoma which cross reacted with gestational choriocarcinoma. The antibody was raised against whole choriocarcinoma cells and human chorionic gonadotropin (hCG) cross reactivity was excluded. The purified antibody was iodinated with 131I and successfully imaged BeWo choriocarcinoma transplanted in nude mice; however, imaging of choriocarcinoma in a patient was verified only after resection. It is our belief that failure to sufficiently concentrate the antibody in the tumor before operation was due to blocking factor in the serum of the patient. Blocking factor and hCG dropped postoperatively. Blocking factor activity in 15 patients with metastatic trophoblastic disease was monitored and, like hCG, was found to be a sensitive indicator of the presence of disease. Its efficacy may be in the small number of patients without hCG but with persistent disease.

References

Jan 1, 1982·AJR. American Journal of Roentgenology·F H DeLandD M Goldenberg

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Citations

Aug 1, 1986·American Journal of Obstetrics and Gynecology·P C HoH K Ma
Jan 1, 1987·American Journal of Obstetrics and Gynecology·R L WahlW H Beierwaltes
Sep 1, 1989·American Journal of Reproductive Immunology : AJRI·C A LabarrereO H Althabe
Apr 1, 1986·American Journal of Reproductive Immunology and Microbiology : AJRIM·C A Labarrere, O H Althabe
Jan 1, 1988·Critical Reviews in Oncology/hematology·J L Murray, M W Unger

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