Chorionic Histiocytic Hyperplasia is Associated With Chronic Inflammatory Lesions in the Placenta

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
Philip J KatzmanBin Zhang

Abstract

Background Chorionic histiocytic hyperplasia (CHH) is a cellular proliferation at the base of the chorion that was identified by the authors in examining placentas for chronic chorioamnionitis (CC). This study is a retrospective review of cases diagnosed with CHH, describing its incidence alone and with associated lesions, and the immunophenotype of lesional cells. Design In this retrospective study, a laboratory information system search over a 34-month period using the key phrase "chorionic stromal" was performed. Cases identified were reviewed for presence of the following: CC, chronic villitis (CV), chronic deciduitis (CD), maternal (MIR), and fetal (FIR) acute inflammatory responses, meconium deposition; and whether CD3 immunostaining was performed. Incidences were tabulated and compared with known prevalences in our population. Select cases were stained with various immunostains to identify cell lineage and X and Y fluorescent probes to identify fetal or maternal cell origin in cases with male infants. Results Eighty cases of CHH were identified during the study period. Incidences of inflammatory lesions associated with CHH were: CV (54/80, 68%), CD (32/80, 40%), CC (25/80, 31%), MIR (39/80, 49%), and FIR (9/80, 11%). Onl...Continue Reading

References

Nov 18, 2004·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Payal KapurBeverly Barton Rogers
Sep 2, 2006·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·David MyersonScott R Hyde
Jan 2, 2007·Obstetrics and Gynecology·William M CurtinPhilip J Katzman
Aug 10, 2012·Journal of Korean Medical Science·Bo Kyung KooJong-Hoon Kim
Dec 3, 2014·Seminars in Perinatology·Philip J Katzman
Mar 11, 2015·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Philip J KatzmanNancy Wang

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Citations

Feb 10, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Raymond W RedlineShabnam Zarei

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