PMID: 2104604Jan 1, 1990Paper

Chorismic acid, a key metabolite in modification of tRNA

Journal of Bacteriology
Tord G HagervallGlenn R Björk

Abstract

Chorismic acid is the common precursor for the biosynthesis of the three aromatic amino acids as well as for four vitamins. Mutants of Escherichia coli defective in any of the genes involved in the synthesis of chorismic acid are also unable to synthesize uridine 5-oxyacetic acid (cmo5U) and its methyl ester (mcmo5U). Both modified nucleosides are normally present in the wobble position of some tRNA species. Mutants defective in any of the specific pathways leading to phenylalanine, tyrosine, tryptophan, folate, enterochelin, ubiquinone, and menaquinone have normal levels of cmo5U and mcmo5U in their tRNA. The presence of shikimic acid in the growth medium restores the ability of an aroD mutant to synthesize cmo5U, while O-succinylbenzoate, which is an early intermediate in the synthesis of menaquinone, does not. Thus, chorismic acid is a key metabolite in the synthesis of these two modified nucleosides in tRNA. The absence of chorismic acid blocks the formation of cmo5U and mcmo5U at the first step, which might be the formation of 5-hydroxyuridine. This results in an unmodified U in the wobble position of tRNA(1Val) and in most of the tRNAs normally containing cmo5U and mcmo5U. Since cmo5U and mcmo5U are synthesized under anae...Continue Reading

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Citations

May 23, 2013·Acta Crystallographica. Section D, Biological Crystallography·Robert T ByrneDavid G Waterman
Jan 24, 2018·Nucleic Acids Research·Isao MasudaYa-Ming Hou
May 17, 2013·Nature·Bradley J Landgraf, Squire J Booker
May 1, 2014·EcoSal Plus·Glenn R Björk, Tord G Hagervall
Nov 1, 2005·EcoSal Plus·Glenn R Björk, Tord G Hagervall
Dec 4, 2003·Molecular and Cellular Biology·Hamid R Kalhor, Steven Clarke
Oct 29, 2003·Biochimica Et Biophysica Acta·Michael O'Connor

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