Choroid plexus tumor necrosis factor receptor 1: A new neuroinflammatory piece of the complex Alzheimer's disease puzzle

Neural Regeneration Research
Sophie Steeland, Roosmarijn E Vandenbroucke

Abstract

Due to the aging of the population and despite the enormous scientific effort, Alzheimer's disease remains one of the biggest medical and pharmaceutical challenges in current medicine. Novel insights highlight the importance of neuroinflammation as an undeniable player in the onset and progression of Alzheimer's disease. Tumor necrosis factor is a master inflammatory cytokine that signals via tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2, but that also regulates several brain functions in health and disease. However, clinical trials investigating drugs that interfere with the tumor necrosis factor pathway in Alzheimer's disease led to inconclusive results, partially because not only the pro-inflammatory tumor necrosis factor/tumor necrosis factor receptor 1, but also the beneficial tumor necrosis factor/tumor necrosis factor receptor 2 signaling was antagonized in these trials. We recently found that tumor necrosis factor is the main upregulated cytokine in the choroid plexus of Alzheimer's disease patients, signaling via tumor necrosis factor receptor 1. In agreement with this, choroidal tumor necrosis factor/tumor necrosis factor receptor 1 signaling was also upregulated in different Alzheimer's diseas...Continue Reading

References

Apr 8, 2011·Journal of Alzheimer's Disease : JAD·Sonia ChalbotKhalid Iqbal
Nov 8, 2014·Nature Reviews. Drug Discovery·Roosmarijn E Vandenbroucke, Claude Libert
May 17, 2015·Drug Discovery Today·Delphine DemeestereRoosmarijn E Vandenbroucke
Sep 18, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marjana BrkicRoosmarijn E Vandenbroucke
May 24, 2016·Neural Regeneration Research·Sriram BalusuRoosmarijn E Vandenbroucke
Aug 20, 2016·Science·Richard M Ransohoff
Feb 24, 2018·EMBO Molecular Medicine·Sophie SteelandRoosmarijn E Vandenbroucke
May 13, 2018·International Journal of Molecular Sciences·Sophie SteelandRoosmarijn E Vandenbroucke
Jul 28, 2018·Brain : a Journal of Neurology·Melanie DaniPaul Edison

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Citations

Jun 3, 2021·Biomedicines·Isaac G OnyangoGorazd B Stokin

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Methods Mentioned

BETA
transgenic
scanning electron microscopy

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