Choroidal Flow Signal in Late-Onset Stargardt Disease and Age-Related Macular Degeneration: An OCT-Angiography Study

Investigative Ophthalmology & Visual Science
Philipp L MüllerMonika Fleckenstein

Abstract

To investigate the choroidal blood flow in areas within and adjacent to retinal pigment epithelium (RPE) atrophy secondary to late-onset Stargardt disease (STGD1) and age-related macular degeneration (AMD). A total of 43 eyes (23 STGD1 and 20 AMD) of patients with RPE atrophy and 25 eyes of healthy controls without ocular pathology underwent multimodal imaging including optical coherence tomography angiography (OCT-A; PLEX Elite 9000 Swept-Source OCT). Using an exploratory approach, choriocapillaris and deeper choroid OCT-A slabs were evaluated in order to detect differences between STGD1 and AMD. The magnitude of absence-of-flow signal (AFS) was investigated in terms of area-fraction and size-frequency distribution. Qualitative and quantitative analysis of areas of RPE atrophy revealed more pronounced rarefaction of the choriocapillaris flow signal in STGD1 as compared to AMD (AFS area fraction: 33.15% ± 6.86% vs. 31.68% ± 8.39%; P = 0.517), while outside RPE atrophy rarefaction was less pronounced in STGD1 (AFS area fraction: 17.41% ± 5.67% vs. 21.59% ± 6.90%; P < 0.001), to the level of nonsignificance compared to controls (13.27% ± 2.99%, P = 0.368). Given this discrepancy, the ratio of the AFS area fraction within/outside ...Continue Reading

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Citations

Sep 13, 2019·Journal of Clinical Medicine·Rodolfo MastropasquaLisa Toto
Apr 15, 2020·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Alexandra M CoffeyPaul A Constable
Jul 16, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Liran TiosanoSrinivas R Sadda
Aug 25, 2020·Translational Vision Science & Technology·Maria Vittoria CicinelliMaurizio Battaglia Parodi
Aug 6, 2020·Journal of Clinical Medicine·Philipp L MüllerFrank G Holz
Apr 30, 2020·The British Journal of Ophthalmology·Maximilian PfauPhilipp L Müller
Sep 7, 2020·American Journal of Ophthalmology·Philipp L MüllerPeter Charbel Issa
May 21, 2021·Clinical & Experimental Ophthalmology·Rachael C Heath Jeffery, Fred K Chen
Jul 23, 2021·Progress in Retinal and Eye Research·Raphael LejoyeuxJay Chhablani
Oct 14, 2021·Investigative Ophthalmology & Visual Science·Ying V LiuMandeep S Singh
Aug 11, 2020·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Philipp L MüllerFrank G Holz

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