Choroidal ganglion cell plexus and retinal vasculature in monkeys with laser-induced glaucoma

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
C A MayElke Lütjen-Drecoll

Abstract

The choroid of primates possesses an elaborate nitrergic nerve fiber plexus containing a great number of ganglion cells. Postganglionic nerve fibers innervate mainly the choroidal vasculature. In addition, the choroid contains an elastic muscular system closely associated to the vasculature. The goal of the present investigation was to analyze how sustained IOP elevation would affect the choroidal vasculature with its specialized innervation and the adjacent retina. For this purpose the posterior eye segment of 15 rhesus monkeys which after laser coagulation of the trabecular meshwork developed elevated IOP up to 4 years were studied using immunohistochemical and histochemical methods, and scanning electron microscopy of corrosion casts. The most striking finding was a significant reduction of choroidal thickness and loss of choroidal ganglion cells and nerve fibers, especially in the central portion of the choroid. Corrosion casts of the choroidal vasculature showed a slight decrease in capillary density and a decrease in length of the arterioles in glaucomatous eyes. Whole mount preparations of the retina stained for NADPH diaphorase revealed a significant reduction in positively stained amacrine cells, reduction in diameter ...Continue Reading

Citations

Mar 22, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Christian Albrecht May, Thom Mittag
Jan 20, 2004·Experimental Eye Research·Falk SchroedlWinfried L Neuhuber
May 30, 2001·Survey of Ophthalmology·R Naskar, E B Dreyer
Jan 9, 2001·Brain Research. Molecular Brain Research·A Laabich, N G Cooper
Jul 18, 2001·Brain Research. Molecular Brain Research·A LaabichN G Cooper
Aug 2, 2002·Progress in Retinal and Eye Research·Josef FlammerEinar Stefánsson
Apr 27, 2013·Investigative Ophthalmology & Visual Science·Ryan J DashekT Michael Nork
May 3, 2000·Seminars in Ophthalmology·R NaskarE B Dreyer
Nov 13, 2010·Autonomic Neuroscience : Basic & Clinical·Winfried Neuhuber, Falk Schrödl
Jan 2, 2010·Progress in Retinal and Eye Research·Debora L Nickla, Josh Wallman
Nov 18, 2005·Experimental Eye Research·Elke Lütjen-Drecoll
Jun 8, 2013·The EPMA Journal·Josef FlammerAndreas J Flammer
Sep 9, 2004·Journal of Glaucoma·Christian Albrecht May, Elke Lütjen-Drecoll
Dec 21, 2013·Journal of Biomechanical Engineering·Ian C CampbellC Ross Ethier
Jul 2, 2005·Journal of Glaucoma·Carol A Rasmussen, Paul L Kaufman
May 30, 2003·Pharmacological Reviews·Noboru Toda, Tomio Okamura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.