Choroidal Microvasculature Dropout Is Associated with Progressive Retinal Nerve Fiber Layer Thinning in Glaucoma with Disc Hemorrhage

Ophthalmology
Hae-Young Lopilly ParkChan Kee Park

Abstract

We used OCT angiography (OCT-A) to investigate parapapillary choroidal microvasculature dropout (MvD) in glaucomatous eyes with or without disc hemorrhage (DH), and the association with changes in retinal nerve fiber layer (RNFL) thickness. An observational case-control study. Eighty-two open-angle glaucoma (OAG) eyes with DH and 68 OAG eyes without DH that underwent at least 4 serial OCT examinations were included. MvD was defined as complete loss of microvasculature within the choroidal layer of the parapapillary region, as revealed by standardized assessment of OCTA-derived density maps of the vessels of the optic nerve head. The circumferential extent of MvD was measured on OCT-A images. The RNFL thinning rate was calculated using a linear mixed model. Kaplan-Meier survival analysis and the log-rank test were used to compare the cumulative risk ratio of progression between groups stratified by DH and MvD. MvD detection rate, the extent of MvD as measured by the MvD angle, and RNFL thinning rate. MvD was found in 38 (46.3%) eyes with DH at the prior DH site, which was found in only 20 (29.4%) eyes without DH, which was significantly different between the 2 groups (P = 0.025). Patients with progressive glaucoma exhibited sign...Continue Reading

Citations

Jan 3, 2019·Journal of Glaucoma·Harsha L RaoRobert N Weinreb
Mar 6, 2019·Investigative Ophthalmology & Visual Science·Youn Hye JoMichael S Kook
Apr 25, 2019·Acta Ophthalmologica·Ahmad A ArefMahnaz Shahidi
Aug 2, 2019·Investigative Ophthalmology & Visual Science·Eun Ji LeeHyunjoong Kim
Mar 3, 2020·Acta Ophthalmologica·Gyu-Nam KimTae-Woo Kim
Mar 20, 2020·Investigative Ophthalmology & Visual Science·Masoud Aghsaei FardPrem S Subramanian
Feb 14, 2020·Journal of Glaucoma·Harsha L RaoRobert N Weinreb
Jun 14, 2020·Acta Ophthalmologica·Rei SakataUNKNOWN for Lower Normal Pressure Glaucoma Study Members in Japan Glaucoma Society
Sep 11, 2018·Journal of Current Ophthalmology·Sasan Moghimi, Robert N Weinreb
Dec 20, 2018·Translational Vision Science & Technology·Grace M RichterRuikang K Wang
Mar 7, 2020·Current Eye Research·Kazuko OmodakaToru Nakazawa
Sep 24, 2020·The British Journal of Ophthalmology·Harsha Laxmana RaoRobert N Weinreb
Jul 25, 2020·The British Journal of Ophthalmology·Carmen Mendez-HernandezJulian Garcia-Feijoo
Mar 25, 2020·Journal of Glaucoma·Min Hee SuhRobert N Weinreb
Dec 15, 2020·Korean Journal of Ophthalmology : KJO·Jounghan KimTae-Woo Kim
Feb 26, 2021·American Journal of Ophthalmology·Ji Min KwonMin Hee Suh
Jul 10, 2021·Annual Review of Vision Science·Alexi GeevargheseJoel S Schuman
Jan 15, 2022·The British Journal of Ophthalmology·Eleonora MichelettiRobert N Weinreb

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.