Choroidal neovascularization associated with cancer-associated retinopathy

Acta Ophthalmologica
Giuseppe QuerquesEric H Souied

Abstract

To report an unusual association between cancer-associated retinopathy (CAR) associated with invasive thymoma and choriodal neovascularization (CNV), treated by photodynamic therapy (PDT). A 39-year-old man affected with thymoma and paraneoplastic syndrome (myasthenia gravis and diarrhoea) was observed between October 1997 and September 2007. The patient developed progressive visual dysfunction including bilateral visual acuity loss and concentric constriction of visual fields. Ophthalmological, immunological and systemic examinations were performed. Immunological evaluations included an assessment of antibody activity by indirect immunohistochemistry on sectioned rhesus monkey eye, and Western blot reactions upon an extract of pig retina. Fundus ophthalmoscopy and fluorescein angiography revealed retinal vessel attenuation and retinal pigment epithelium degeneration. Electroretinogram suggested both rod and cone dysfunction. Indirect immunohistochemistry identified antibody activity within the photoreceptor outer segments. Western blots on the retina revealed that most of the patient's antibody activity was focused upon a retinal protein antigen approximating 145 kD. These findings share the commonalities of size and retinal d...Continue Reading

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Citations

Nov 26, 2015·Ophthalmic Surgery, Lasers & Imaging Retina·Eric K ChinCharles E Thirkill
Aug 29, 2012·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Thomas L SlamovitsJohn L Keltner
Jan 18, 2013·Ocular Immunology and Inflammation·Chee Kwang Wan, Stephen C Teoh
Apr 3, 2020·Documenta Ophthalmologica. Advances in Ophthalmology·Kei MizobuchiTadashi Nakano
Oct 1, 2011·Seminars in Ophthalmology·Yevgeniy ShildkrotEvangelos S Gragoudas
Aug 24, 2013·Survey of Ophthalmology·Ehsan Rahimy, David Sarraf

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