Choroidal neovascularization associated with extensive macular atrophy and pseudodrusen

Optometry and Vision Science : Official Publication of the American Academy of Optometry
Maurizio B Parodi, G Querques

Abstract

To describe a case of extensive macular atrophy and pseudodrusen complicated by bilateral choroidal neovascularization (CNV). A 53-year-old woman showed extensive macular atrophy at the posterior pole associated with disciform scar in the right eye and fibrotic juxtafoveal CNV in the left eye. The patient underwent a complete ophthalmological examination including fundus autofluorescence, fluorescein angiography, and spectral-domain optical coherence tomography, showing a disciform scar at the posterior pole of the right eye and an extensive macular atrophy associated with a fibrotic juxtafoveal CNV. The patient was previously treated with four and seven intravitreal bevacizumab injections, respectively, in the right eye and in the left eye. Molecular analyses of the ABCA4 gene revealed the variant c.1268A<G. Although the natural course of extensive macular atrophy and pseudodrusen usually leads to the enlargement of the macular atrophy, extensive macular atrophy and pseudodrusen can also complicate with bilateral CNV. Intravitreal bevacizumab can help stop the CNV activity.

References

Oct 16, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Giuseppe QuerquesEric H Souied
Feb 3, 2009·American Journal of Ophthalmology·Christian P HamelBernard Puech
Jun 23, 2009·American Journal of Ophthalmology·Camiel J F BoonCarel B Hoyng
Oct 10, 2009·Ophthalmology·Sandrine A ZweifelYutaka Imamura
Apr 9, 2010·Investigative Ophthalmology & Visual Science·Maurizio Battaglia ParodiFrancesco Bandello
Jan 24, 2012·Investigative Ophthalmology & Visual Science·Giuseppe QuerquesEric H Souied
Feb 5, 2013·Ophthalmology·Giuseppe QuerquesEric H Souied

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Citations

Jul 27, 2020·Translational Vision Science & Technology·Firuzeh RajabianMaurizio Battaglia Parodi
Nov 12, 2020·Journal français d'ophtalmologie·M PierreH Merle

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