Choroidal readaptation to gravity in rats after spaceflight and head-down tilt

Journal of Applied Physiology
J DavetJ Gabrion

Abstract

To determine when choroidal structures were restored after readaptation to Earth gravity or orthostatic position, fine structure and protein distribution were studied in rat choroid plexus dissected either 6 h [Space Life Sciences-2 (SLS-2) experiments] or 2 days [National Institutes of Health-Rodent 1 (NIH-R1) experiments] after a spaceflight, or 6 h after head-down tilt (HDT) experiments. Apical alterations were noted in choroidal cells from SLS-2 and HDT animals, confirming that weightlessness impaired choroidal structures and functions. However, the presence of small apical microvilli and kinocilia and the absence of vesicle accumulations showed that the apical organization began to be restored rapidly after landing. Very enlarged apical microvilli appeared after 2 days on Earth, suggesting increased choroidal activity. However, as distributions of ezrin and carbonic anhydrase II remained altered in both flight and suspended animals after readaptation to Earth gravity, it was concluded that choroidal structures and functions were not completely restored, even after 2 days in Earth's gravity.

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Citations

Mar 10, 2000·Journal of Applied Physiology·C MasseguinJ Gabrion
Apr 15, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yan-Chao LiTsutomu Hashikawa
Feb 13, 2016·Journal of Applied Physiology·Ruth K Globus, Emily Morey-Holton
Apr 28, 2021·Journal of Environmental Science and Health. Part C, Toxicology and Carcinogenesis·Jeffrey S WilleyXiao Wen Mao
Jul 30, 2021·Journal of Neuroscience Research·Hans C LudwigHans C Bock

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