Choroidal thickness changes in obstructive sleep apnea syndrome: a systematic review and meta-analysis

Sleep & Breathing = Schlaf & Atmung
Miao HeWenyong Huang

Abstract

Obstructive sleep apnea syndrome (OSAS) is a common chronic disorder associated with hypoxia and endothelial and vascular dysfunction. Many studies have analyzed choroidal thickness measurements in patients with different severities of OSAS versus normal subjects by optical coherence tomography (OCT), but the results have been inconsistent. Therefore, a meta-analysis was performed to evaluate the choroidal thickness changes in OSAS measured by OCT. Pertinent studies were retrieved by a comprehensive search of PubMed, Embase, Web of Science, and the Cochrane Library from inception to August 2015. For continuous outcomes, the weighted mean difference (WMD) and 95 % confidence interval (CI) were calculated by using a random effects model. Seven case-control studies were included in the final meta-analysis, containing a total of 784 eyes (558 in the OSAS group and 226 in normal controls). The results showed that subfoveal choroidal thickness (SFCT) was significantly reduced compared with normal controls, with pooled WMD -8.06 (95 % CI -15.72 to -0.41) for mild OSAS, -29.99 (95 % CI -52.40 to -7.58) for moderate OSAS, and -53.72 (95 % CI -88.95 to -18.48) for severe OSAS. Choroidal thickness at 1 mm temporal to the fovea and at 1 mm...Continue Reading

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Citations

Apr 27, 2016·Sleep & Breathing = Schlaf & Atmung·Rajiv RamanRamakrishnan Nagarajan
Sep 3, 2016·The British Journal of Ophthalmology·Andrea GovettoJean Pierre Hubschman
Apr 6, 2019·Sleep & Breathing = Schlaf & Atmung·Bekir KüçükŞenol Delibaş
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Jul 24, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·P Naranjo-BonillaB Jurado-Gámez

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