Choroidal thickness predicts ocular growth in normal chicks but not in eyes with experimentally altered growth

Clinical & Experimental Optometry : Journal of the Australian Optometrical Association
Debora L Nickla, Kristen Totonelly

Abstract

In hatchling chicks, the thickness of the choroid is quite variable. It has been postulated that thickness per se or the changes occurring during early life might play a causal role in the regulation of ocular growth. We tested this notion by measuring ocular dimensions in several experimental conditions that alter ocular growth and in the fellow eyes. Chicks aged 12 to 14 days wore monocular lenses or diffusers (+10 D, n = 23; -10 D, n = 16; diffusers, n = 16) for four to five days. Fellow untreated eyes served as controls. A separate group of completely untreated birds aged eight days were also tested (n = 12). We tested two drugs known to alter ocular growth. The dopaminergic agonist quinpirole was injected daily for five days into eyes wearing negative lenses (n = 47). The muscarinic agonist oxotremorine was injected one time into normal eyes (n = 27). All eyes were measured using high-frequency A-scan ultrasonography at the start and end of the experiment. Spearman's correlation coefficient was used in all analyses. Choroidal thickness predicted ocular growth rates in normal eyes: eyes with thinner choroids grew faster than those with thicker choroids (p = 0.0001). Furthermore, there was a negative correlation between init...Continue Reading

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Citations

Oct 8, 2016·Scientific Reports·Zhengwei ZhangZhifeng Wu
Apr 25, 2018·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Ranjay ChakrabortyRichard A Stone
Dec 21, 2018·Investigative Ophthalmology & Visual Science·Frances RuckerChristopher Taylor
Mar 1, 2019·Investigative Ophthalmology & Visual Science·David TroiloLyndon Jones
Mar 27, 2019·Investigative Ophthalmology & Visual Science·Liqin JiangChristine F Wildsoet
Jun 21, 2017·Current Eye Research·Seray Aslan Bayhan, Hasan Ali Bayhan
Aug 21, 2020·The British Journal of Ophthalmology·Chee Wai WongMarcus Ang
Dec 17, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Cheng PengJinsong Zhang
Aug 12, 2020·Vestnik oftalmologii·E P TaruttaN A Tarasova
Jun 21, 2019·Investigative Ophthalmology & Visual Science·Min WangFrank Schaeffel
Mar 10, 2021·Investigative Ophthalmology & Visual Science·Barbara Swiatczak, Frank Schaeffel
May 15, 2018·Experimental Eye Research·Jacob G Sivak, Jeremy M Sivak

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