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Chr21 protein-protein interactions: enrichment in products involved in intellectual disabilities, autism and Late Onset Alzheimer Disease

bioRxiv

Dec 12, 2019

Julia ViardAude-Marie Lepagnol-Bestel

Abstract

Intellectual disability (ID) found in Down syndrome (DS), which is characterized by an extra copy of 234 genes on Chr21 is poorly understood. We first used two DS mouse models that either display an extra copy of the Dyrk1A gene or of the mouse Chr16 syntenic region. Exome sequencing of...read more

Mentioned in this Paper

Screening Generic
Yeasts
Protein-Protein Interaction
Dendritic Spines
DYRK1A gene
Down Syndrome
DSCAM
Receptor
Ion Channel
Alzheimer Disease, Late Onset
10
Paper Details
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Chr21 protein-protein interactions: enrichment in products involved in intellectual disabilities, autism and Late Onset Alzheimer Disease

bioRxiv

Dec 12, 2019

Julia ViardAude-Marie Lepagnol-Bestel

PMID: 990872606

DOI: 10.1101/2019.12.11.872606

Abstract

Intellectual disability (ID) found in Down syndrome (DS), which is characterized by an extra copy of 234 genes on Chr21 is poorly understood. We first used two DS mouse models that either display an extra copy of the Dyrk1A gene or of the mouse Chr16 syntenic region. Exome sequencing of...read more

Mentioned in this Paper

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Receptor
Ion Channel
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