CHRNA4 rs1044396 is associated with smoking cessation in varenicline therapy

Frontiers in Genetics
Juliana Rocha SantosPaulo C J L Santos

Abstract

The large individual variability in response to drugs for smoking cessation suggests that specific treatments can be more effective in particular subgroups of smokers. In the context of personalized medicine, the main aim of the present study was to evaluate whether the CHRNA4 and CHRNB2 polymorphisms are associated with response to smoking cessation therapies in patients from a smoker assistance program. This cohort study enrolled 483 smoking patients who received behavioral counseling and drug treatment (varenicline, bupropion, and/or nicotine replacement therapy). Smoking cessation success was considered for patients who completed 6 months of continuous abstinence. Fagerström test for nicotine dependence (FTND) and Issa situational smoking scores were analyzed for nicotine dependence. The CHRNA4 (rs1044396 and rs2236196) and CHRNB2 (rs2072660 and rs2072661) polymorphisms were genotyped by high resolution melting analysis. Patients with rs1044396 CC genotype had lower success rate in treatment with varenicline (29.5%) compared with carriers of CT or TT genotypes (50.9%; p = 0.007, n = 167). The CT or TT genotypes were associated with higher odds ratio for success (OR = 1.67, 95% CI = 1.10-2.53, p = 0.02), in a multivariate mo...Continue Reading

References

Feb 21, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A MarkouG F Koob
May 15, 2003·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Hong XianSeth A Eisen
Jun 5, 2003·Reviews of Physiology, Biochemistry and Pharmacology·R C HoggD Bertrand
Oct 7, 2004·The Medical Clinics of North America·Khatija N PaperwallaStephen M Saravay
Oct 27, 2004·Psychological Medicine·Christina N LessovPamela A F Madden
May 13, 2005·Journal of Medicinal Chemistry·Jotham W CoeBrian T O'Neill
Oct 3, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R S PappasD L Ashley
Jan 18, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Marissa A EhringerJoanna S Zeiger
Sep 5, 2007·Archives of General Psychiatry·Kent E HutchisonHeather M Haughey
Jun 7, 2008·Biological Psychiatry·Ming D LiRobert C Elston
Jul 3, 2008·Human Molecular Genetics·David V ContiUNKNOWN Pharmacogenetics of Nicotine Addiction and Treatment Consortium
Jan 20, 2009·Journal of Neurogenetics·Gary E Swan, Christina N Lessov-Schlaggar
Sep 17, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kenneth A PerkinsJessica L Briski
Aug 26, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennifer WesselAndrew W Bergen
Mar 30, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Shizhong HanJoel Gelernter
May 25, 2011·The Pharmacogenomics Journal·G E SwanA W Bergen
Oct 20, 2011·Genes, Brain, and Behavior·S-J TsaiJ-P Hwang
Nov 4, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David P KingPeter W Park
Dec 20, 2011·Circulation·Véronique L RogerUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Dec 20, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Timothy SpruellMarcus R Munafò
Feb 9, 2012·Addictive Behaviors·Jinxue WeiXiaohong Ma
Mar 1, 2012·Neuroscience and Biobehavioral Reviews·P M GreenwoodThomas Espeseth
Jul 20, 2012·Genetic Testing and Molecular Biomarkers·Renata Alonso Gadi SoaresAlexandre Costa Pereira
Nov 7, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jaqueline S IssaAlexandre C Pereira
Jan 5, 2013·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Jaqueline Scholz Issa
Jan 29, 2013·Genes, Brain, and Behavior·H M KamensM A Ehringer
Jan 9, 2014·JAMA : the Journal of the American Medical Association·Marie NgEmmanuela Gakidou
Feb 12, 2014·International Journal of Cardiology·Jaqueline S IssaAlexandre C Pereira
Jun 5, 2014·Pharmacogenomics·Marieke QuaakConstant P van Schayck

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Citations

Apr 7, 2018·BMC Medical Genetics·Paulo Roberto Xavier TomazPaulo Caleb Júnior Lima Santos
Sep 16, 2017·Frontiers in Human Neuroscience·Peiyu HuangMinming Zhang
Dec 17, 2020·Expert Opinion on Drug Metabolism & Toxicology·Yadira X Perez-Paramo, Philip Lazarus

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Methods Mentioned

BETA
pharmacotherapy
genotyping
PCR

Software Mentioned

SPSS
Haploview

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