Chromaffin cell survival and host dopaminergic fiber recovery in a patient with Parkinson's disease treated by cografts of adrenal medulla and pretransected peripheral nerve. Case report

Journal of Neurosurgery
Isao DateT Ohmoto

Abstract

A 55-year-old woman with severe Parkinson's disease was treated by cografting adrenal medulla with pretransected peripheral nerve into the bilateral caudate nuclei. The patient showed modest improvement of her akinesia; this effect persisted for 1 year after transplantation, when she suddenly died from upper gastrointestinal bleeding unrelated to the grafting procedure. At autopsy, a large number of tyrosine hydroxylase-immunoreactive chromaffin cells were observed within the caudate graft sites and a dense network of host dopaminergic fibers was visualized. This autopsy finding is very important for the field of experimental and clinical chromaffin cell grafting because it is the first evidence that cografts using pretransected peripheral nerve might enhance the survival of chromaffin cells and the recovery of host dopaminergic fibers in humans suffering from Parkinson's disease.

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Citations

Mar 31, 2009·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Isao Date, Takao Yasuhara
Sep 5, 1998·Brain Research. Brain Research Reviews·G L Willis, S M Armstrong
Jul 12, 2002·Drug Discovery Today·Cesario V Borlongan, Paul R Sanberg
Jan 3, 2006·Journal of Neurologic Physical Therapy : JNPT·Maria J Amador, James D Guest
Mar 6, 2007·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·Isao Date
Aug 12, 2005·Neurorehabilitation and Neural Repair·W-L Kuan, R A Barker
Sep 9, 1999·Cell Transplantation·H YoshidaT Ohmoto
Jan 1, 2009·Reviews in the Neurosciences·Sergey V Anisimov
Feb 7, 2020·Journal of Neuroscience Methods·Nader El SeblaniGreg A Gerhardt
May 18, 2021·Frontiers in Neuroscience·Chengxiao MaMaohong Cao

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Methods Mentioned

BETA
cografts

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