Chromate-induced sulfur starvation and mRNA mistranslation in yeast are linked in a common mechanism of Cr toxicity.

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Sara L HollandSimon V Avery

Abstract

Toxicity of the environmental carcinogen chromate is known to involve sulfur starvation and also error-prone mRNA translation. Here we reconcile those facts using the yeast model. We demonstrate that: (i) cysteine and methionine starvation mimic Cr-induced translation errors, (ii) genetic suppression of S starvation suppresses Cr-induced mistranslation, and (iii) mistranslation requires cysteine and methionine biosynthesis. Therefore, Cr-induced S starvation is the cause of mRNA mistranslation. This establishes a single, novel pathway mediating the toxicity of chromate.

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Jul 25, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sara L Holland, Simon V Avery

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Citations

Apr 15, 2011·Letters in Applied Microbiology·R R GaddameediS S Singh
Nov 18, 2015·Scientific Reports·Elena Moreno-MartinezSimon V Avery
Feb 12, 2011·The Biochemical Journal·Simon V Avery
Jun 11, 2016·Journal of Basic Microbiology·José Oscar BonillaLiliana Beatriz Villegas
Jan 9, 2020·Journal of Basic Microbiology·Xiaoyu ZhangZhiwei Huang
Aug 2, 2011·Metallomics : Integrated Biometal Science·Sara L Holland, Simon V Avery
Oct 24, 2018·Frontiers in Microbiology·Cindy VallièresSimon V Avery

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