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Chromatin accessibility profiling uncovers genetic- and T2D disease state-associated changes in cis-regulatory element use in human islets

bioRxiv

Sep 22, 2017

Shubham KhetanMichael L. Stitzel

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Abstract

Genetic and environmental factors both contribute to islet dysfunction and failure, resulting in type 2 diabetes (T2D). The islet epigenome integrates these cues and can be remodeled by genetic and environmental variation. However, our knowledge of how genetic variants and T2D disease s...read more

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Chromatin accessibility profiling uncovers genetic- and T2D disease state-associated changes in cis-regulatory element use in human islets

bioRxiv

Sep 22, 2017

Shubham KhetanMichael L. Stitzel

DOI: 10.1101/192922

Abstract

Genetic and environmental factors both contribute to islet dysfunction and failure, resulting in type 2 diabetes (T2D). The islet epigenome integrates these cues and can be remodeled by genetic and environmental variation. However, our knowledge of how genetic variants and T2D disease s...read more

Mentioned in this Paper

NKX6-2 gene
Landscapes
Luciferases
MTNR1B protein, human
Quantitative Trait Loci
17
10

Similar Papers Found In These Feeds

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