Chromatin changes induced by Pb and Cd in human cells

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Gaspar BanfalviGabor Nagy

Abstract

Our earlier data on the apoptotic effects of heavy metals (Cd, Hg, Ni, CrVI, and Ag) and irradiation (gamma and UV-B) indicated that cellular effects exerted on chromatin structure differ from one other. These observations suggested that chromatin distortions could be characteristic to the genotoxic agent. This notion raised questions whether or not (a) a specific genotoxic agent causes the same chromatin changes in different cell types, (b) closely related toxic compounds could be distinguished based on their chromatin toxicity. To answer these questions we have compared Cd induced toxicity in different cell types. The same Cd-specific chromatin changes were seen in human K562, Chinese hamster ovary and murine preB cells. K562 cells were chosen for fluorescent microscopy to compare chromatin damages caused by Cd and Pb. Characteristic distortions allowed a clear distinction between Cd and Pb toxicity at micromolar concentrations. The visualization of these changes is relatively easy and fast carrying the potential of early detection of heavy metal poisoning.

References

Jan 1, 1981·Immunogenetics·A ZieglerP Wernet
Mar 15, 1984·European Journal of Biochemistry·G BanfalviF Antoni
Jan 1, 1995·Cancer Investigation·K S Kasprzak
Dec 4, 2003·Mutation Research·Ellen K Silbergeld
Jan 30, 2004·Annual Review of Medicine·Herbert Needleman
Jan 20, 2005·Environmental and Molecular Mutagenesis·Daniela BonackerGisela H Degen
May 24, 2005·Apoptosis : an International Journal on Programmed Cell Death·G BanfalviA G Basnakian
Jan 30, 2007·Apoptosis : an International Journal on Programmed Cell Death·Gaspar BanfalviAlexei Basnakian
Aug 19, 2007·Apoptosis : an International Journal on Programmed Cell Death·Kinga UjvarosiGaspar Banfalvi
Aug 23, 2007·DNA and Cell Biology·Gyorgy TrencsényiGaspar Banfalvi
Jul 12, 2008·Cell Biology and Toxicology·Soumik AgarwalShelley Bhattacharya
Apr 18, 2009·Toxicology and Applied Pharmacology·Pius Joseph
Mar 12, 2010·DNA and Cell Biology·Gabor NagyGaspar Banfalvi
Jul 14, 2010·International Journal of Environmental Research and Public Health·Clement G YedjouPaul B Tchounwou

❮ Previous
Next ❯

Citations

Feb 23, 2013·ISRN Hematology·Ronit Vogt Sionov
Apr 3, 2014·Applied Microbiology and Biotechnology·Gabor NagyGaspar Banfalvi
Jul 16, 2014·Apoptosis : an International Journal on Programmed Cell Death·Gaspar Banfalvi
Oct 8, 2013·DNA and Cell Biology·Gabor NagyGaspar Banfalvi
May 20, 2015·Toxicology and Applied Pharmacology·Natalia PawlasSławomir Kasperczyk
Dec 5, 2014·Environmental Science and Pollution Research International·Yang LiDahai Yan
Jan 22, 2015·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Gabor NagyGaspar Banfalvi
Dec 3, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Melinda TuraniAdam Kemeny-Beke
Nov 3, 2016·BioMed Research International·Wenzhen YuanXiangkai Li
Oct 27, 2016·Apoptosis : an International Journal on Programmed Cell Death·Gabor KiralyGaspar Banfalvi
Nov 9, 2018·The Journal of Toxicological Sciences·Liyun HeGaochun Zhu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics Chromatin Complexes (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on chromatin complexes and their role in cancer epigenetics.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cancer Epigenetics and Chromatin (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on chromatin and its role in cancer epigenetics please follow this feed to learn more.

Related Papers

Apoptosis : an International Journal on Programmed Cell Death
Gaspar BanfalviGabor Nagy
Toxicology in Vitro : an International Journal Published in Association with BIBRA
Erzsebet FarkasGaspar Banfalvi
Apoptosis : an International Journal on Programmed Cell Death
Gaspar BanfalviAlexei G Basnakian
Toxicology in Vitro : an International Journal Published in Association with BIBRA
Mariann GacsiGaspar Banfalvi
© 2021 Meta ULC. All rights reserved