Chromatin condensation and terminal differentiation process in embryonic chicken lens in vivo and in vitro

Experimental Cell Research
M SanwalM F Counis

Abstract

During embryonic chick lens differentiation, the epithelial cells become transformed into elongated fibres. Concomitantly, the fibre nuclei undergo degeneration and high molecular weight (HMW) DNA breaks down due to nuclear endodeoxyribonuclease activity. An electronmicroscopic study of lens epithelial and fibre nuclei was made at different stages of chick embryonic development, both in vivo and in vitro. The in vitro conditions are conducive to the expression of endogenous endodeoxyribonuclease activity in fibres. In both conditions we observed condensation of chromatin. The organization of some nuclear material into distinct linear arrays followed by streaming of nuclear material into the cytoplasm is recorded only in vitro. Such a condition may lead to acceleration of the process of aging in lens fibres.

References

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May 1, 1977·Developmental Biology·M F CounisY Courtois
Jul 8, 1977·Science·H Bloemendal
Jan 31, 1985·Biochemical and Biophysical Research Communications·M F CounisC J Skidmore
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Citations

Jun 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·J Graw, A Liebstein
Jan 1, 1989·The International Journal of Biochemistry·M F CounisY Courtois
Jul 1, 1989·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·M F CounisB Allinquant
Dec 1, 1996·Differentiation; Research in Biological Diversity·M A Wride
Sep 13, 2003·Differentiation; Research in Biological Diversity·Esmond J Sanders, Eve Parker
Jun 9, 2006·Differentiation; Research in Biological Diversity·Qin YanDavid Wan-Cheng Li
Apr 7, 1997·The Journal of Cell Biology·S Bassnett, D Mataic
Dec 1, 1995·The Journal of Biological Chemistry·A TorrigliaM F Counis
Jul 3, 2021·Experimental Eye Research·Lisa BrennanMarc Kantorow

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