Chromatin fiber functional organization: some plausible models

The European Physical Journal. E, Soft Matter
A Lesne, J-M Victor

Abstract

We here present a modeling study of the chromatin fiber functional organization. Multi-scale modeling is required to unravel the complex interplay between the fiber and the DNA levels. It suggests plausible scenarios, including both physical and biological aspects, for fiber condensation, its targeted decompaction, and transcription regulation. We conclude that a major role of the chromatin fiber structure might be to endow DNA with allosteric potentialities and to control DNA transactions by an epigenetic tuning of its mechanical and topological constraints.

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Citations

Jan 19, 2013·Acta Biotheoretica·Annick Lesne
Jul 16, 2009·Médecine sciences : M/S·Annick Lesne
Oct 28, 2009·Genome Research·Cédric VaillantAlain Arneodo
Oct 1, 2008·Biological Reviews of the Cambridge Philosophical Society·Annick Lesne
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Feb 14, 2006·The European Physical Journal. E, Soft Matter·A Lesne
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