Chromatin Insulators and Topological Domains: Adding New Dimensions to 3D Genome Architecture

Genes
Navneet K Matharu, Sajad H Ahanger

Abstract

The spatial organization of metazoan genomes has a direct influence on fundamental nuclear processes that include transcription, replication, and DNA repair. It is imperative to understand the mechanisms that shape the 3D organization of the eukaryotic genomes. Chromatin insulators have emerged as one of the central components of the genome organization tool-kit across species. Recent advancements in chromatin conformation capture technologies have provided important insights into the architectural role of insulators in genomic structuring. Insulators are involved in 3D genome organization at multiple spatial scales and are important for dynamic reorganization of chromatin structure during reprogramming and differentiation. In this review, we will discuss the classical view and our renewed understanding of insulators as global genome organizers. We will also discuss the plasticity of chromatin structure and its re-organization during pluripotency and differentiation and in situations of cellular stress.

References

May 1, 1992·Molecular and Cellular Biology·R Kellum, P Schedl
Apr 1, 1997·Current Opinion in Genetics & Development·P K Geyer
Jan 27, 1998·The Journal of Biological Chemistry·S NabirochkinT Heidmann
Dec 10, 1999·Cell·F L Sun, S C Elgin
Dec 7, 2000·Molecular Cell·T I GerasimovaV G Corces
Feb 5, 2002·Genes & Development·Adam G WestGary Felsenfeld
Feb 16, 2002·Science·Job DekkerNancy Kleckner
Nov 12, 2002·Nature Genetics·David CarterPeter Fraser
Apr 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Parimal Majumder, Haini N Cai
Oct 1, 2003·Nature Genetics·Robert-Jan PalstraWouter de Laat
Jan 30, 2004·Molecular and Cellular Biology·Emily J KuhnPamela K Geyer
Jun 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Timur M Yusufzai, Gary Felsenfeld
Sep 14, 2004·Nature Genetics·Wenqiang YuRolf Ohlsson
Oct 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Larisa MelnikovaPavel Georgiev
Nov 3, 2004·Biology of the Cell·Maya Capelson, Victor G Corces
Dec 3, 2004·Molecular Cell·Chi-Yun PaiVictor G Corces
Jan 19, 2005·Cell Cycle·Elena Klenova, Rolf Ohlsson
Oct 8, 2005·Molecular Cell·Maya Capelson, Victor G Corces
Oct 19, 2005·The Journal of Biological Chemistry·Pierre-Antoine DefossezEric Gilson
Apr 22, 2006·The EMBO Journal·Maya Capelson, Victor G Corces
Jun 6, 2006·Cell·Ken-ichi NomaShiv I S Grewal
Jul 25, 2006·Nature Genetics·Elissa P Lei, Victor G Corces
Sep 5, 2006·Molecular Cell·Ko IshiharaMitsuyoshi Nakao
Mar 7, 2007·Molecular and Cellular Biology·Young Soo YoonKarl Pfeifer
Apr 11, 2007·Molecular and Cellular Biology·Sandra GoetzeRoel van Driel
May 9, 2007·Molecular and Cellular Biology·Rashmi U PathakRakesh K Mishra
Aug 21, 2007·Nucleic Acids Research·Xingguo ZhuDorothy Tuan
Sep 25, 2007·Genetics·Sergey RodinPavel Georgiev
Oct 5, 2007·Current Opinion in Genetics & Development·Julie A Wallace, Gary Felsenfeld
Mar 29, 2008·EMBO Reports·Anton GolovninPavel Georgiev

❮ Previous
Next ❯

Citations

Jan 31, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Darya ChetverinaPaul Schedl
Oct 17, 2017·Nucleic Acids Research·Nikolay ZolotarevPavel Georgiev
Jan 22, 2019·Genes, Chromosomes & Cancer·Andrew J FritzRonald Berezney
Mar 30, 2017·Bioscience Reports·Zhenhua Hu, Wee-Wei Tee
Oct 7, 2020·Nature Reviews. Drug Discovery·Navneet Matharu, Nadav Ahituv

❮ Previous
Next ❯

Methods Mentioned

BETA
gypsy
Hi-C
chromosomal aberrations
ChIP-Seq
immunoprecipitation
ubiquitination
PARylation
transgenic

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology
Dean A Jackson
Current Opinion in Genetics & Development
Kevin Van Bortle, Victor G Corces
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
Takashi Tada
© 2021 Meta ULC. All rights reserved