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Chromatin loops as allosteric modulators of enhancer-promoter interactions

PLoS Computational Biology

Oct 24, 2014

Boryana DoyleLeonid A Mirny

Abstract

The classic model of eukaryotic gene expression requires direct spatial contact between a distal enhancer and a proximal promoter. Recent Chromosome Conformation Capture (3C) studies show that enhancers and promoters are embedded in a complex network of looping interactions. Here we use...read more

Mentioned in this Paper

Muscle Rigidity
Chromosome Structures
Chromatin Loop
Nucleosomes
Genome
Macromolecular Alteration
Promoter
Drosophila
Nucleosome Location
Gene Expression
19
182
Paper Details
References
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  • Citations31
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  • References45
  • Citations31
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Chromatin loops as allosteric modulators of enhancer-promoter interactions

PLoS Computational Biology

Oct 24, 2014

Boryana DoyleLeonid A Mirny

PMID: 25340767

DOI: 10.1371/journal.pcbi.1003867

Abstract

The classic model of eukaryotic gene expression requires direct spatial contact between a distal enhancer and a proximal promoter. Recent Chromosome Conformation Capture (3C) studies show that enhancers and promoters are embedded in a complex network of looping interactions. Here we use...read more

Mentioned in this Paper

Muscle Rigidity
Chromosome Structures
Chromatin Loop
Nucleosomes
Genome
Macromolecular Alteration
Promoter
Drosophila
Nucleosome Location
Gene Expression
19
182

Similar Papers Found In These Feeds

Nuclear Architecture

The 3-D organization of chromatin is an important factor in the regulation of gene expression. Find the latest research on nuclear architecture here.

Nuclear Architecture (Keystone)

The 3-D organization of chromatin is an important factor in the regulation of gene expression. Find the latest research on nuclear architecture in this feed.

Related Papers

Biophysical Journal

Roles of DNA looping in enhancer-blocking activity

Biophysical JournalDecember 31, 2010
Naoko TokudaGeorge Chikenji
Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire

Communication over a large distance: enhancers and insulators

Biochemistry and Cell Biology = Biochimie Et Biologie CellulaireAugust 5, 2003
Vladimir A BondarenkoVasily M Studitsky
Paper Details
References
  • References45
  • Citations31
12345
  • References45
  • Citations31
1234
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