Chromatin Regulators in Pancreas Development and Diabetes

Trends in Endocrinology and Metabolism : TEM
Stephanie A Campbell, Brad G Hoffman

Abstract

The chromatin landscape of a cell is dynamic and can be altered by chromatin regulators that control nucleosome placement and DNA or histone modifications. Together with transcription factors, these complexes help dictate the transcriptional output of a cell and, thus, balance cell proliferation and differentiation while restricting tissue-specific gene expression. In this review, we describe current research on chromatin regulators and their roles in pancreas development and the maintenance of mature β cell function, which, once elucidated, will help us better understand how β cell differentiation occurs and is maintained. These studies have so far implicated proteins from several complexes that regulate DNA methylation, nucleosome remodeling, and histone acetylation and methylation that could become promising targets for diabetes therapy and stem cell differentiation.

References

Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·F C LynnM S German
Jul 5, 2007·Developmental Cell·Qiao ZhouDouglas A Melton
Aug 20, 2008·Molecular and Cellular Biology·Cécile HaumaitreRaphaël Scharfmann
Oct 8, 2008·Molecular and Cellular Biology·Min WuAli Shilatifard
Jan 27, 2009·Cell·Jiang I WuGerald R Crabtree
Feb 24, 2009·Development·Amanda NottkeYang Shi
Apr 10, 2009·Annual Review of Biochemistry·Cedric R Clapier, Bradley R Cairns
Jul 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ahmad M KhalilJohn L Rinn
Feb 26, 2010·Genome Research·Reena BhandareKlaus H Kaestner
Dec 21, 2010·PLoS Genetics·Eric M MendenhallBradley E Bernstein
Dec 24, 2010·Science·UNKNOWN modENCODE ConsortiumManolis Kellis
Feb 22, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Fong Cheng Pan, Chris Wright
Jun 15, 2011·Cell·Stuart H Orkin, Konrad Hochedlinger
Dec 14, 2011·The Biochemical Journal·Ersin AkinciJonathan M W Slack
Jun 20, 2012·FEBS Letters·Panagis Filippakopoulos, Stefan Knapp
Jun 26, 2012·Seminars in Cell & Developmental Biology·Dana Avrahami, Klaus H Kaestner
Dec 29, 2012·Genes & Development·Joris van ArensbergenJorge Ferrer
Feb 23, 2013·Genes & Development·Senta GeorgiaAnil Bhushan
Feb 26, 2013·The Journal of Clinical Investigation·Nuria C BramswigKlaus H Kaestner
Mar 7, 2013·Nature Structural & Molecular Biology·Irene Cantone, Amanda G Fisher
Apr 10, 2013·Diabetes·H Siebe SpijkerEelco J P de Koning
May 30, 2013·Development·Luigi AloiaLuciano Di Croce
Jul 19, 2013·The Journal of Clinical Investigation·Shuangli GuoRoland Stein

❮ Previous
Next ❯

Citations

Sep 15, 2020·The FEBS Journal·Ben Vanderkruk, Brad G Hoffman
Sep 16, 2017·Scientific Reports·Sara CervantesRosa Gasa
Apr 30, 2020·Stem Cell Research & Therapy·Fei HeFu-Rong Li
Apr 24, 2021·World Journal of Diabetes·Simon LecoutreChristophe Breton
Sep 30, 2020·Mechanisms of Development·Niloufer P Dumasia, Prasad S Pethe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Progress in Drug Research. Fortschritte Der Arzneimittelforschung. Progrès Des Recherches Pharmaceutiques
Peter W Atadja
Frontiers in Bioscience : a Journal and Virtual Library
V Sartorelli, P L Puri
© 2022 Meta ULC. All rights reserved