Jun 16, 2015

Chromatin Remodelers: From Function to Dysfunction

Genes
Gernot Längst, Laura Manelyte

Abstract

Chromatin remodelers are key players in the regulation of chromatin accessibility and nucleosome positioning on the eukaryotic DNA, thereby essential for all DNA dependent biological processes. Thus, it is not surprising that upon of deregulation of those molecular machines healthy cells can turn into cancerous cells. Even though the remodeling enzymes are very abundant and a multitude of different enzymes and chromatin remodeling complexes exist in the cell, the particular remodeling complex with its specific nucleosome positioning features must be at the right place at the right time in order to ensure the proper regulation of the DNA dependent processes. To achieve this, chromatin remodeling complexes harbor protein domains that specifically read chromatin targeting signals, such as histone modifications, DNA sequence/structure, non-coding RNAs, histone variants or DNA bound interacting proteins. Recent studies reveal the interaction between non-coding RNAs and chromatin remodeling complexes showing importance of RNA in remodeling enzyme targeting, scaffolding and regulation. In this review, we summarize current understanding of chromatin remodeling enzyme targeting to chromatin and their role in cancer development.

  • References145
  • Citations20

References

  • References145
  • Citations20

Citations

Mentioned in this Paper

Study
Histone antigen
RNA, Untranslated
Enzymes, antithrombotic
Regulation of Biological Process
Metal Working Fluid
Complex (molecular entity)
Protein Deregulation
Biologic Development
Nucleosome Location

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