Chromatin remodelling and epigenetic state regulation by non-coding RNAs in the diseased heart

Non-coding RNA Research
F De Majo, M Calore

Abstract

Epigenetics refers to all the changes in phenotype and gene expression which are not due to alterations in the DNA sequence. These mechanisms have a pivotal role not only in the development but also in the maintenance during adulthood of a physiological phenotype of the heart. Because of the crucial role of epigenetic modifications, their alteration can lead to the arise of pathological conditions. Heart failure affects an estimated 23 million people worldwide and leads to substantial numbers of hospitalizations and health care costs: ischemic heart disease, hypertension, rheumatic fever and other valve diseases, cardiomyopathy, cardiopulmonary disease, congenital heart disease and other factors may all lead to heart failure, either alone or in concert with other risk factors. Epigenetic alterations have recently been included among these risk factors as they can affect gene expression in response to external stimuli. In this review, we provide an overview of all the major classes of chromatin remodellers, providing examples of how their disregulation in the adult heart alters specific gene programs with subsequent development of major cardiomyopathies. Understanding the functional significance of the different epigenetic marks...Continue Reading

Citations

May 6, 2019·Pathology Oncology Research : POR·Jingchun QinHuixuan Li
Dec 3, 2020·Cellular and Molecular Life Sciences : CMLS·Britt MossinkNael Nadif Kasri
Sep 27, 2019·Food Research International·Lívia Beatriz Aparecida Ribeiro SilvaThomas Prates Ong
Oct 23, 2020·Clinical Epigenetics·Sandra AtlanteCarlo Gaetano
Dec 10, 2020·Current Developments in Nutrition·Radha O JoshiPrachi Kukshal
Jan 24, 2021·Seminars in Cancer Biology·Mohammad Imran KhanHasan Mukhtar
Sep 20, 2020·Cancer Letters·Jun CaoMeiyu Fang
Nov 19, 2021·Biochemical Genetics·Meenu Ghai, Farzeen Kader

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Methods Mentioned

BETA
ubiquitination
methylation profiling
acetylation
CHAST
histone

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