Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants
Proceedings of the National Academy of Sciences of the United States of America
Oct 29, 2013
Stephen C. J. ParkerNISC Comparative Sequencing Program Authors
PMID: 24127591
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Abstract
Chromatin-based functional genomic analyses and genomewide association studies (GWASs) together implicate enhancers as critical elements influencing gene expression and risk for common diseases. Here, we performed systematic chromatin and transcriptome profiling in human pancreatic isle...read more
Mentioned in this Paper
Enhancer brand
Gene Expression
Luciferases
Associated Study
Regulatory Protein
Chromatin
Locus Control Region
Tissue Specificity
Chromatin Immunoprecipitation
Enhancer Elements, Genetic
8
1
1
408
1
2
Paper Details
References
- References32
- Citations8
Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci
Cell MetabolismNovember 3, 2010Michael L. StitzelFrancis S Collins137
Charting histone modifications and the functional organization of mammalian genomes
Nature Reviews. GeneticsJanuary 1, 2011Vicky W ZhouBradley E. Bernstein21692
Five years of GWAS discovery
American Journal of Human GeneticsJanuary 13, 2012Peter M. VisscherJian Ying Yang635218412
Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors
ScienceDecember 7, 2012Inderpreet Kaur SurJussi Taipale371101991
Locus control regions
BloodNovember 1, 2002Qiliang LiGeorge Stamatoyannopoulos12892
A CTCF-independent role for cohesin in tissue-specific transcription
Genome ResearchMay 1, 2010Dominic SchmidtDuncan T. Odom
Gene Ontology term overlap as a measure of gene functional similarity
BMC BioinformaticsAugust 4, 2008Meeta Mistry, Paul Pavlidis1121
Selective inhibition of tumor oncogenes by disruption of super-enhancers
CellApril 11, 2013Jakob LovénRichard Allen Young2433148712
Interpreting noncoding genetic variation in complex traits and human disease
Nature BiotechnologyNovember 1, 2012Lucas D. Ward, Manolis Kellis12723ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia
Genome ResearchSeptember 1, 2012Stephen G LandtMichael P. Snyder2315260112
1234
- References32
- Citations8
Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma
LeukemiaAugust 1, 2014Maurizio AfferWalter Michael Kuehl2871
Enhancer biology and enhanceropathies
Nature Structural & Molecular BiologyMarch 1, 2014Edwin R Smith, Ali Shilatifard11386
Laying a solid foundation for Manhattan--'setting the functional basis for the post-GWAS era'
Trends in Genetics : TIGApril 1, 2014Xiao-Yang ZhangMathieu Lupien11155Global transcriptome analysis and enhancer landscape of human primary T follicular helper and T effector lymphocytes
BloodDecember 11, 2014Jason S WeinsteinPatrick G Gallagher2751NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers
Proceedings of the National Academy of Sciences of the United States of AmericaJanuary 14, 2014Hongfang WangJon Christopher Aster91661
Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells
ELifeNovember 19, 2014Wen-Xian FuDiane J Mathis81661
Strategies to fine-map genetic associations with lipid levels by combining epigenomic annotations and liver-specific transcription profiles
GenomicsAugust 1, 2014Ken Sin LoGuillaume Lettre1137
Enhancing the understanding of asthma
Nature ImmunologyAugust 1, 2014Golnaz VahediJohn J O'Shea1128
1
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Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants
Proceedings of the National Academy of Sciences of the United States of America
Oct 29, 2013
Stephen C. J. ParkerNISC Comparative Sequencing Program Authors
PMID: 24127591
Abstract
Chromatin-based functional genomic analyses and genomewide association studies (GWASs) together implicate enhancers as critical elements influencing gene expression and risk for common diseases. Here, we performed systematic chromatin and transcriptome profiling in human pancreatic isle...read more
Mentioned in this Paper
Enhancer brand
Gene Expression
Luciferases
Associated Study
Regulatory Protein
8
1
1
408
1
2
Related Papers
Paper Details
References
- References32
- Citations8
Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci
Cell MetabolismNovember 3, 2010Michael L. StitzelFrancis S Collins137Charting histone modifications and the functional organization of mammalian genomes
Nature Reviews. GeneticsJanuary 1, 2011Vicky W ZhouBradley E. Bernstein21692Five years of GWAS discovery
American Journal of Human GeneticsJanuary 13, 2012Peter M. VisscherJian Ying Yang635218412Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors
ScienceDecember 7, 2012Inderpreet Kaur SurJussi Taipale371101991Locus control regions
BloodNovember 1, 2002Qiliang LiGeorge Stamatoyannopoulos12892A CTCF-independent role for cohesin in tissue-specific transcription
Genome ResearchMay 1, 2010Dominic SchmidtDuncan T. OdomGene Ontology term overlap as a measure of gene functional similarity
BMC BioinformaticsAugust 4, 2008Meeta Mistry, Paul Pavlidis1121Selective inhibition of tumor oncogenes by disruption of super-enhancers
CellApril 11, 2013Jakob LovénRichard Allen Young2433148712Interpreting noncoding genetic variation in complex traits and human disease
Nature BiotechnologyNovember 1, 2012Lucas D. Ward, Manolis Kellis12723ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia
Genome ResearchSeptember 1, 2012Stephen G LandtMichael P. Snyder2315260112
1234
- References32
- Citations8
Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma
LeukemiaAugust 1, 2014Maurizio AfferWalter Michael Kuehl2871Enhancer biology and enhanceropathies
Nature Structural & Molecular BiologyMarch 1, 2014Edwin R Smith, Ali Shilatifard11386Laying a solid foundation for Manhattan--'setting the functional basis for the post-GWAS era'
Trends in Genetics : TIGApril 1, 2014Xiao-Yang ZhangMathieu Lupien11155Global transcriptome analysis and enhancer landscape of human primary T follicular helper and T effector lymphocytes
BloodDecember 11, 2014Jason S WeinsteinPatrick G Gallagher2751NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers
Proceedings of the National Academy of Sciences of the United States of AmericaJanuary 14, 2014Hongfang WangJon Christopher Aster91661Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells
ELifeNovember 19, 2014Wen-Xian FuDiane J Mathis81661Strategies to fine-map genetic associations with lipid levels by combining epigenomic annotations and liver-specific transcription profiles
GenomicsAugust 1, 2014Ken Sin LoGuillaume Lettre1137Enhancing the understanding of asthma
Nature ImmunologyAugust 1, 2014Golnaz VahediJohn J O'Shea1128
1
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