Chromatin structure and gene regulation: a dynamic view of enhancer function

Nucleus
Diana A Stavreva, Gordon L Hager

Abstract

Localized chromatin organization is now recognized as an important determinant of cell identity and developmental pathways. Recent studies have demonstrated that these epigenetic states are unexpectedly dynamic and malleable. In this Extra view we will highlight the transient nature of stimulus-induced enhancer accessibility and its importance for transcription regulation. Using glucocorticoid receptor (GR) as a model system we will discuss spatiotemporal relationships between receptor/chromatin interactions, lifetimes of the DNase I hypersensitivity sites (DHSs), long-range interactions, and gene regulation. We propose that differential temporal activation and utilization of distal regulatory elements plays a role in directing divergent stimulus-induced transcriptional programs.

References

Sep 14, 2006·Journal of Cell Science·Z Dave SharpMichael A Mancini
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Micol S Rothman, Margaret E Wierman
Mar 18, 2008·Molecular Cell·Sam JohnGordon L Hager
Apr 10, 2009·Annual Review of Biochemistry·Cedric R Clapier, Bradley R Cairns
Apr 16, 2010·Nature·Tae-Kyung KimMichael E Greenberg
May 21, 2010·PLoS Biology·Francesca De SantaGioacchino Natoli
Jul 24, 2010·Journal of Neuroendocrinology·B L Conway-CampbellS L Lightman
Aug 20, 2010·Nature·Michael H KageyRichard A Young
Sep 16, 2010·Nature Reviews. Neuroscience·Stafford L Lightman, Becky L Conway-Campbell
Aug 30, 2011·Molecular and Cellular Endocrinology·Becky L Conway-CampbellStafford L Lightman
Dec 21, 2011·Methods in Molecular Biology·Florian MuellerJames G McNally
Apr 10, 2012·Biochimica Et Biophysica Acta·Diana A StavrevaGordon L Hager
Jun 19, 2012·Nature Reviews. Genetics·Ross C Hardison, James Taylor
Aug 8, 2012·Nature Reviews. Genetics·François Spitz, Eileen E M Furlong
Jan 22, 2013·Cell·Renato OstuniGioacchino Natoli
Feb 5, 2013·Cell·David G Johnson, Sharon Y R Dent
Mar 19, 2013·Molecular and Cellular Endocrinology·Tina B MirandaGordon L Hager
Apr 4, 2013·Journal of Medical Engineering & Technology·R C BhakeS L Lightman
Jul 10, 2013·Nature Reviews. Genetics·Antoine CoulonDaniel R Larson
Dec 10, 2013·Nature Structural & Molecular Biology·Stephanie A MorrisGordon L Hager
Dec 18, 2013·Nature Reviews. Genetics·Ty C Voss, Gordon L Hager
Feb 22, 2014·Trends in Genetics : TIG·Rebecca M Terns, Michael P Terns
Jul 19, 2014·Nature Communications·Tatsuya MorisakiJames G McNally
Feb 19, 2015·Nature Reviews. Molecular Cell Biology·Benjamin L Allen, Dylan J Taatjes
Mar 12, 2015·Nature Reviews. Molecular Cell Biology·Ana Pombo, Niall Dillon
May 11, 2015·Cell·Maria J E KosterH Th Marc Timmers
Aug 11, 2015·Genome Biology·Britta A M Bouwman, Wouter de Laat
Aug 12, 2015·Genes·Daniël P MeltersYamini Dalal

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Citations

Dec 1, 2017·Molecular Brain·Yuka HamaHidenao Sasaki
Aug 11, 2019·Proceedings of the National Academy of Sciences of the United States of America·Nadine ProvençalElisabeth B Binder
Jun 5, 2020·International Journal of Molecular Sciences·Sung Kyung ChoiJueng Soo You
Jan 30, 2021·The Biochemical Journal·Martin StortzValeria Levi

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Methods Mentioned

BETA
immunoprecipitation
ChIP
super-resolution microscopy

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