Chromatogram-Bioactivity Correlation-Based Discovery and Identification of Three Bioactive Compounds Affecting Endothelial Function in Ginkgo Biloba Extract

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Hong LiuHong-Liang Yao

Abstract

Discovery and identification of three bioactive compounds affecting endothelial function in Ginkgo biloba Extract (GBE) based on chromatogram-bioactivity correlation analysis. Three portions were separated from GBE via D101 macroporous resin and then re-combined to prepare nine GBE samples. 21 compounds in GBE samples were identified through UFLC-DAD-Q-TOF-MS/MS. Correlation analysis between compounds differences and endothelin-1 (ET-1) in vivo in nine GBE samples was conducted. The analysis results indicated that three bioactive compounds had close relevance to ET-1: Kaempferol-3-O-α-l-glucoside, 3-O-{2-O-{6-O-[P-OH-trans-cinnamoyl]-β-d-glucosyl}-α-rhamnosyl} Quercetin isomers, and 3-O-{2-O-{6-O-[P-OH-trans-cinnamoyl]-β-d-glucosyl}-α-rhamnosyl} Kaempferide. The discovery of bioactive compounds could provide references for the quality control and novel pharmaceuticals development of GRE. The present work proposes a feasible chromatogram-bioactivity correlation based approach to discover the compounds and define their bioactivities for the complex multi-component systems.

References

Sep 11, 2002·Journal of Chromatography. a·Teris A van Beek
Jul 17, 2007·Analytical and Bioanalytical Chemistry·Pei ChenJames Harnly
Dec 1, 2012·Journal of Applied Physiology·Hsiu-Chung OuShin-Da Lee

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Citations

Mar 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jessica GómezAlejandro Tapia
Nov 7, 2020·Journal of Pharmaceutical and Biomedical Analysis·Lingmei LiuShufang Wang

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Methods Mentioned

BETA
Light Scattering
Assay

Software Mentioned

Biotest
Chromeleon
SPSS

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