Chromatographic analysis of penicillins in pharmaceutical formulations and biological fluids

Journal of Separation Science
Victoria F SamanidouIoannis N Papadoyannis

Abstract

Natural penicillin (benzylpenicillin) is the oldest antibiotic observed by Alexander Fleming in 1928. To broaden its spectrum of activity, natural penicillin was modified, giving rise to a group of antibiotics under the name 'penicillins'. Although an increasing number of bacteria appear to be resistant to them, penicillins are used to treat a variety of bacterial infections including Gram-positive, Gram-negative aerobic and anaerobic bacteria. Consequently, they are widely used in human and veterinary medicine to prevent and treat diseases. This review covers the analytical methodologies, mainly chromatographic, employed to the penicillins determination in pharmaceutical formulations, biological fluids and in production-scale fermentations reported in the literature. Results of published assays are comparatively presented focusing on sample preparation regarding isolation and purification, chromatographic conditions and method validation. Information on chemical structure, spectrum of activity and action mechanism of common penicillins has also been given.

References

Jan 1, 1992·Journal of Pharmaceutical and Biomedical Analysis·A O Akanni, J S Ayim
May 1, 1992·Journal of Pharmaceutical and Biomedical Analysis·M B DevaniT M Patel
Jan 1, 1991·Journal of Pharmaceutical and Biomedical Analysis·M A AbounassifR A Gad-Kariem
Jan 1, 1991·Journal of Pharmaceutical and Biomedical Analysis·V GautierG Vinçon
Jan 1, 1991·Journal of Pharmaceutical and Biomedical Analysis·E M Abdel-Moety
Dec 1, 1994·Journal of Pharmaceutical and Biomedical Analysis·M S GarcíaV Ródenas
Apr 22, 1994·Journal of Chromatography. B, Biomedical Applications·J LalR C Gupta
Apr 1, 1993·Journal of Pharmaceutical and Biomedical Analysis·M J AkhtarM A Khan
Jun 1, 1996·Journal of Pharmaceutical and Biomedical Analysis·E RoetsJ Hoogmartens
Jun 28, 1996·Journal of Chromatography. B, Biomedical Applications·V AugeyF Bressolle
Apr 26, 1996·Journal of Chromatography. B, Biomedical Applications·W J Krauwinkel, N J Volkers-Kamermans
Jun 20, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·Y H LiH Yamada
Nov 21, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·B PérezM Arboix
Mar 14, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·P O ErahP N Shaw
Jun 5, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·Z YongxinJ Hoogmartens
Jun 25, 1998·Journal of Pharmaceutical and Biomedical Analysis·F BelalM Eid
Jul 8, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·M GroverS Singh
Aug 6, 1998·Journal of Chromatography. a·W M Niessen
Oct 10, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·Y LuoL R Soma
Dec 5, 1998·Biosensors & Bioelectronics·J LiuK Chen
Feb 24, 1999·The Science of the Total Environment·R HirschK L Kratz
Oct 8, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·A MenelaouF Bochner
Mar 4, 2000·Journal of Pharmaceutical and Biomedical Analysis·W R LaCourse, C O Dasenbrock
Sep 14, 2000·Journal of Chromatography. a·O BrüggemannK Mosbach
Mar 29, 2001·Journal of Pharmaceutical and Biomedical Analysis·A Aghazadeh, G Kazemifard
Sep 29, 2001·International Journal of Pharmaceutics·T Tokumura, Y Machida
May 29, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Paul MetzD N Gilbert
Jun 1, 2002·Journal of Pharmaceutical and Biomedical Analysis·Shalini Joshi
Jun 7, 2002·Journal of Pharmaceutical and Biomedical Analysis·Hesham Salem, Gamal A Saleh
Jun 14, 2002·Journal of Pharmaceutical and Biomedical Analysis·Alireza GhassempourMassoud Adrangui
Jul 13, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·R TrittlerK Kümmerer
Nov 1, 2002·Journal of Pharmaceutical and Biomedical Analysis·Mojtaba ShamsipurShamsoddin Tabatabaei
Dec 18, 2002·Journal of Midwifery & Women's Health·Elissa Lane Miller
Jul 11, 2003·Journal of Pharmaceutical and Biomedical Analysis·Genowefa Pajchel, Stefan Tyski
Sep 5, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Chonghua LiCharles H Nightingale
Dec 31, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Katarzyna MichalskaStefan Tyski
Apr 7, 2004·Journal of Chromatography. a·Genowefa PajchelStefan Tyski
May 12, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Oscar AldereteNelly Castro Torres
Jun 9, 2004·Seminars in Pediatric Infectious Diseases·B Lee Ligon
Oct 13, 2004·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Lixiao XuYan Xiao
Sep 1, 2005·Journal of Chromatography. a·Genowefa PajchelStefan Tyski
Jan 3, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Patricia PuigMarta Calull
Jan 25, 2006·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·F A Nour El-DienEman Y Z A Farag
Jan 1, 1988·Journal of Pharmaceutical and Biomedical Analysis·L CampanellaM Tomassetti
Jan 1, 1988·Journal of Pharmaceutical and Biomedical Analysis·V GironaJ Bolòs
Jan 1, 1986·Journal of Pharmaceutical and Biomedical Analysis·C M SelavkaK Bratin
Mar 1, 1993·Talanta·H HeO S Wolfbeis

Citations

Apr 19, 2011·Drug Testing and Analysis·Victoria F Samanidou, Eftichia G Karageorgou
Jun 27, 2009·Journal of Separation Science·Miriam Martínez-HuelamoJosé Barbosa

Related Concepts

High Pressure Liquid Chromatography Procedure
Pharmaceutical Preparations
Penicillin

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